NMN Supplements benefits for Boosting Metabolism and Weight Loss

Nobody enjoys gaining unhealthy weight and having a protruding jelly belly. The health of the current population is progressively deteriorating due to a sedentary lifestyle, poor diet, and growing environmental crises. In addition to causing diseases, all of these factors speed up the ageing process. Seeing an obese 25-year-old who is dying from cardiovascular disease is not an unusual sight. Thanks to developments in longevity science and the healthcare industry, there remains hope amidst this chaos.

After countless years of study, scientists have now developed several important compounds that specifically target each molecular process associated with ageing. Nicotinamide mononucleotide (NMN) is a groundbreaking anti-ageing supplement that has the power to completely transform your life. The NMN supplement has the potential to revolutionize the way you maximize your health and vitality because of its beneficial qualities.

So grab a bite to eat while we explore the advantages of NMN, the emperor of anti-ageing supplements, which helps with weight loss and metabolism stimulation.

Understanding what is metabolism?

The sum of reactions that occur in our body in each cell and provide the body with energy is called metabolism. The energy produced is used for cellular processes and the synthesis of organic material. All living organisms take up nutrients and substances from the environment required to build blocks for movement, growth, development, and reproduction. Enzymes are responsible for these processes.

There are two types of metabolic processes: anabolism and catabolism. Anabolism is a process where simple molecules combine to form complex molecules. Catabolism is the vice versa of anabolism. Adenosine triphosphate (ATP) is the energy currency of the body, and its synthesis takes place in the inner mitochondrial membrane. Our body uses 1/10th of its energy to process food into fuel.

The basal metabolic rate is the number of calories your body needs to function while inactive, and the amount varies from person to person. People with metabolic disorders such as Wilson's disease, mitochondrial diseases, hemochromatosis, and Gaucher's disease struggle with weight loss. Individuals with a fast BMR burn more calories than those with a slow BMR.

How do NMN supplements improve metabolism?

NMN supplements help in improving metabolism in the following ways

• Boosting NAD+ levels-Nicotinamide adenine dinucleotide (NAD+) is a molecule directly derived from NMN and is essential for controlling metabolism and various other cellular functions. Supplements containing NAD+ can improve mitochondrial function, necessary for effective energy production and metabolism.
• Enhancing mitochondrial biogenesis- Cells' powerhouses, the mitochondria, are in charge of transforming food-derived energy into a form that can be used. Research has demonstrated that NMN can promote the process of mitochondrial biogenesis, the synthesis of new mitochondria. This can enhance the cell's ability to produce energy and optimize its metabolism.
• Promoting SIRT1 activity- The protein essential for controlling longevity and metabolism is called SIRT1. NMN can activate SIRT1, improving insulin sensitivity, raising energy expenditure, and strengthening mitochondrial performance.
• Protecting against oxidative stress- An imbalance between free radicals and antioxidants can lead to oxidative stress, harming cells and disrupting metabolism. Due to its antioxidant qualities, NMN can help shield cells from oxidative stress, maintaining the health of the mitochondria and metabolism.
• Regulating Gene Expression- NMN can affect the patterns of gene expression, especially those linked to ageing and metabolism. It can support healthy ageing processes and metabolic balance by regulating gene expression.
  

How do NMN supplements aid weight loss?

When there is too much fat and not enough physical activity to convert that fat into energy, weight gain results. This is a result of impaired fat metabolism, as well as slowed metabolism. Supplements that fight aging, like NMN, promote weight loss by focusing on the important metabolism-related players.

It helps activate Sirtuins, as previously mentioned, and obesity is frequently linked to inflammation and low NAD+ levels, both of which can impair Sirtuin function. As mentioned earlier, sirtuins are a major target for preventing obesity and early mortality because they regulate inflammation, metabolism, brain function, and calorie restriction.

One of the best methods to activate Sirtuins is through caloric restriction, but this is easier said than done. Sirtuins are highly reliant on NAD+ concentrations. Therefore, increasing the levels of Sirtuins through the replenishment of cells with NAD+ can ultimately prove beneficial in managing obesity and aiding in weight loss.

Supplements such as NMN, which raise NAD+ levels, also activate SIRT1, improving metabolism and having antioxidant, neuroprotective, and cardioprotective properties. According to a study published in Cell Metabolism, mice given doses of 100 or 300 mg/kg of NMN for 12 months showed weight reductions of 4% and 9%, respectively. It's interesting to note that NMN increased energy expenditure and oxygen consumption rather than decreasing appetite to cause weight loss (Mills et al., 2016b).

Given that being overweight puts one at a considerable risk of developing several chronic illnesses, NMN could be a useful tool for promoting healthy weight management.

Benefits of NMN supplements

The cells in our body require NAD+ for their cellular processes. NMN is the precursor of NAD+, and NAD+ helps regulate various functions of the cell, including energy metabolism, DNA repair, gene expression, and cellular stress responses. Taking NMN helps produce more NAD+ levels, and it is important to know the benefits of NMN. The benefits are listed below:

• Supports Brain Health: NMN supplementation counteracts age-related cognitive decline by replenishing NAD+ levels, and improving memory, coordination, and neurovascular health while preventing the formation of beta-amyloid plaques in mice (Kiss et al., 2020).
• Aids in Reproductive Health: In a study, reproductively aged female mice receiving low-dose NMN exhibited enhanced birth rates, shorter time to pregnancy, and improved in vitro fertilization outcomes, potentially linked to NMN's weight-management benefits. This suggests that low-dose NMN supplementation could become a non-invasive strategy to support fertility in older women (Bertoldo et al., 2020).
• Promotes Longevity: By increasing NAD+ levels, a crucial coenzyme is involved in cellular energy production, DNA repair, and sirtuin activation—all of which contribute to improved cellular function and longevity.
• Boosts NAD+ Levels:  When you consume NMN, your cells convert it into NAD+, a molecule responsible for various cellular functions, including energy production.
• DNA Repair: Increased NAD+ levels through NMN support the body in repairing damaged DNA, reducing the risk of mutations that may lead to cancer or other age-related diseases.
• Telomere Length: When cells divide, the DNA at the end of our chromosomes grows shorter, and telomere shortening begins to damage our genes. Sirtuins help by stabilizing telomere length.
• Heart Health: NMN lowers oxidative stress that tends to increase with age, leading to inflammation of arteries and reducing the chance of heart diseases like atherosclerosis and coronary artery disease.
• Metabolic Health: NMN plays a key role in regulating glucose and lipid metabolism, benefiting people by preventing diseases like diabetes and other metabolic disorders.
• Sirtuin Activation: NAD+ activates sirtuins, a group of enzymes with various functions, including DNA repair, inflammation regulation, and stress response. The SIRT1 gene is known to be involved in cellular stress resistance.
• Circadian Clock Genes: The circadian clock depends on a complex network of genes, including CLOCK and BMAL1, which interact with various cofactors, such as NAD+, to regulate the timing of circadian processes.
• Antioxidant: NAD+ plays a role in the body's antioxidant defence. By increasing NAD+ levels, NMN helps combat oxidative stress and protect cells from damage caused by reactive oxygen species (ROS).

How to consume NMN supplements

Begin with 250 mg of NMN daily. If you notice any changes, gradually increase the dosage to 500 mg, and then to 1000 mg. Be patient with the results.

How to use it?

• Take 1 capsule after lunch
• Safe for individuals having high blood pressure, hypertension, and high blood sugar levels 
• Avoid if pregnant or breastfeeding

Dosage guidelines:

• For individuals aged 18-30: Start with 250 mg of NMN or Decode Age Longevity.
• For individuals aged 31-50: Begin with 500 mg.
• For individuals aged 50 and above: Start with 1000 mg.
• Athletes aged 18-30: Opt for 500 mg.
• Athletes aged 30 and above: Choose 1000 mg.

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Conclusion

By increasing NAD+ levels, supporting mitochondrial function, controlling gene expression, and assisting in weight loss, NMN supplements improve metabolism. These benefits extend to longevity, reproductive health, cognitive function, and overall cellular well-being, making NMN a potential supplement for ageing gracefully.

FAQS

1) What are NMN Supplements, and how do they work to boost metabolism and promote weight loss?
NMN supplements are precursors of NAD+ molecules which are involved in energy metabolism. They work by boosting the levels of NAD+, a coenzyme involved in various metabolic processes, which can promote weight loss and reverse ageing.

2) Are NMN Supplements safe to take, and what are the recommended dosages?
NMN supplements are generally safe to take at recommended dosages, but more research is needed to determine their long-term safety. Recommended dosages range from 125-500mg per day.

3) Can NMN Supplements help individuals burn fat and lose weight, even without changes to diet or exercise habits?
While NMN supplements may promote weight loss and boost metabolism. Changes to diet, exercise habits along with supplementation work in harmony to promote healthy weight

4) How does NMN impact energy levels and overall physical performance?
NMN can impact energy levels and physical performance by increasing NAD+ levels, which can enhance mitochondrial function and cellular metabolism.

5) How can individuals incorporate NMN Supplements into a comprehensive approach to weight loss and overall health?
NMN supplements can be incorporated into a comprehensive approach to weight loss and overall health by combining them with a balanced diet, regular exercise, and other healthy habits such as getting enough sleep and managing stress. However, it's important to consult a healthcare professional before starting any supplement regimen.

 

References

Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. I. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.

https://doi.org/10.1016%2Fj.cmet.2016.09.013 

Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., ... & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience, 42, 527-546.

https://doi.org/10.1007/s11357-020-00165-5 

Bertoldo, M. J., Listijono, D. R., Ho, W. H. J., Riepsamen, A. H., Goss, D. M., Richani, D., ... & Wu, L. E. (2020). NAD+ repletion rescues female fertility during reproductive ageing. Cell Reports, 30(6), 1670-1681.

https://doi.org/10.1016/j.celrep.2020.01.058