What Is Calcium Alpha Ketoglutarate (Ca-akg)?

What Is Calcium Alpha Ketoglutarate (Ca-akg)?

      Ca-AKG plays an important role in metabolism. It is effective in reducing uremia, stimulating wound healing, controlling lipid levels, and treating chronic renal insufficiency in hemodialysis patients. It also improves nitrogen metabolism and reduces metabolic stress to improve stamina in humans.

      It is actively transported by cells to multiple organs. Lack of precursors, genetic defects, or toxin exposures lead to deficiency of AKG. It also helps in the oxidation of fatty acids, amino acids, and glucose.

      What is Ca-AKG?

      Alpha-ketoglutarate is a molecule in the Krebs cycle which determines the rate of the citric acid cycle of the organism. It also extends the lifespan of adults by inhibiting ATP synthase and TOR. It is an important source of glutamine that stimulates protein synthesis, inhibits protein degradation in muscles, and constitutes an important metabolic fuel for cells.

      AKG is a compound created naturally in our body but diminishes with age. It promotes longer health and prevents inflammation. It modulates the pathways responsible for healthy ageing including DNA demethylation.

      The Science behind Ca-AKG

      Alpha-ketoglutarate is the link between carbon and nitrogen metabolism. It is a metabolite of The Citric Acid cycle. It contributes to metabolism. It regulated longevity in some organisms like D.melanogaster and C.elegans. A study revealed that when mice were given AKG treatment, the lifespan of female mice and male lifespan increased to 16.6% and 9.6% respectively (Rhoads & Anderson, 2020).

      It is an important source of glutamine and glutamate which are responsible for protein synthesis, preventing protein degradation, and is fuel for gastrointestinal cells. AKG is the precursor of glutamine-main source of energy for intestinal cells. It is involved in collagen metabolism and stabilizes the immune system. 

      Potential Health Benefits of Ca-AKG

      Metabolic support

      In diabetes, α-Ketoglutaric acid (AKG) shows promise in reducing hyperglycemia. It works by preventing hepatic gluconeogenesis by blocking serpina1e signalling. This novel strategy targets important pathways involved in glucose regulation, highlighting AKG's potential as a therapeutic agent and opening the door for creative approaches to diabetes management (Yuan et al., 2022).

       

      Amino Acid Transformation

      Alpha-ketoglutarate (AKG) functions as an intermediary in the Krebs cycle, thereby aiding in the conversion of amino acids and supporting amino acid transformation. Amino acids are shielded from oxidative damage during metabolic processes by their antioxidative properties (S. Liu et al., 2018).

      Anti-Inflammatory Properties

      Alpha-ketoglutarate improves the PXR-regulated detoxification pathway and inhibits NF-κB-mediated inflammation. AKG probably helps metabolic processes in amino acid transformation by influencing important pathways, promoting protein synthesis, and controlling amino acid metabolism (He et al., 2017).

      DNA Protection through Methylation

      A study showed middle-aged adults benefit from supplementing with alpha-ketoglutarate (AKG) to support DNA protection through methylation. Because of its capacity to improve methylation processes, also helps in maintaining genomic integrity, which may reduce biological ageing and improve cellular health in general in this population.

      Energy Regulation and Metabolism

      • Production of ATP: The electron transport chain receives high-energy molecules from the citric acid cycle, such as FADH2 and NADH. This chain, which is found in the mitochondria, makes it easier for cells to produce ATP, which is their main source of energy.
      • Enhanced Cell Respiration: Ca-AKG facilitates effective cellular respiration through its participation in the citric acid cycle. This is essential for the digestion of nutrients and the subsequent release of energy that cells need for a variety of processes, such as the production of new cells, the contraction of muscles, and the preservation of cellular integrity.

      The Promising Potential of Ca-AKG

      When Ca binds to AKG it becomes Ca-AKG. This form is more effective and highly bioavailable. It is used for longevity benefits, reversing biological ageing, and supporting heart and cell health. It also increases AMPK activity and inhibits mTOR. Some supplements provide AKG when consumed. 

      Clinical trials also were done on humans with different diseases. It helped in promoting muscle growth, wound healing, increasing energy levels, immunity, and fast recovery after surgery. Also responsible for the elimination of radical oxygen species and for keeping the skin hydrated (Yang et al., 2021).

      Enhanced Longevity

      An increase in the risk of mortality, along with a notable decline and failure in fertility and body performance, are the most evident functional changes associated with animal ageing. Circumorhabditis elegans, the common fruit fly (Drosophila melanogaster), Rattus norvegicus domestica, laboratory mice (Mus musculus), and roundworms (Rattus norvegicus domestica) all appear to share highly conserved survival pathways and mechanisms. 

      Consequently, numerous research projects carried out in these traditional models have demonstrated the critical role that AKG plays in extending lifespan and improving health (Naeini et al., 2023).

      Health Span Improvement

      Research shows that AKG is an antioxidant that interferes with nitrogen and ammonia balance, and affects epigenetic and immune regulation helping to extend the human health span (Gyanwali et al., 2022).

      Ca-AKG and the Body's Vital Functions

      The body uses calcium alpha-ketoglutarate (Ca-AKG) for several essential processes that support general health and well-being. Although studies are still being conducted, the following are some ways that Ca-AKG may affect vital body functions:

      • Antioxidant Defence: Alpha-ketoglutarate, including the calcium form, may have antioxidant qualities according to certain research. Free radicals are countered by antioxidants, which lowers oxidative stress and may shield cells from harm.
      • Metabolism and Gluconeogenesis: The effects of calcium-AKG on glucose metabolism have been studied. Studies suggest that it might affect gluconeogenesis, the body's glucose-producing process. This may have consequences for diseases like diabetes, where an irregular regulation of glucose is a major issue.
      • Nitric Oxide Synthesis: Ca-AKG might help to boost the synthesis of nitric oxide. Vasodilation is influenced by nitric oxide, which may improve blood flow and cardiovascular health.

      Collagen Synthesis

      Alpha-ketoglutarate helps produce collagen by increasing the pool of proline residues through glutamate and about 25% of dietary AKG is converted into proline in the enterocytes. Proline is the primary substrate for collagen synthesis and plays an important role in collagen metabolism (Wu et al., 2016).

      Stem Cell Proliferation

      A study showed that α-Ketoglutarate, or AKG, was a significant factor in making human pluripotent stem cells differentiate early. The results point to AKG's potential role in promoting stem cell proliferation and differentiation in regenerative medicine applications by suggesting that it quickens the early phases of cellular specialisation (TeSlaa et al., 2016).

      Potential Side Effects and Considerations

      Although many people believe calcium alpha-ketoglutarate (Ca-AKG) supplements to be safe, it's important to be aware of any potential side effects and considerations before adding them to your routine. The following are some things to remember:

      • Gastrointestinal Distress: High Ca-AKG dosages have the potential to cause gastrointestinal distress, such as nausea and diarrhea. It might be possible to lessen these effects by gradually increasing the dosage from the beginning.
      • Individual Variability: Different people may react differently to supplements. A person may not experience the same results from something that works well for them. Observe how your body reacts and change the dosage as necessary.
      • Kidney Function: People who already have kidney problems should be cautious when thinking about taking supplements containing calcium-aKG. High dosages have the potential to worsen renal dysfunction, so speaking with a healthcare provider is advised.
      • Medications Interactions: Ca-AKG may interact with some medications. If you are taking any prescription medications, especially those that affect kidney function or metabolism, talk to your doctor before taking Ca-AKG supplements.
      • Allergic Reactions: Although uncommon, some people may experience allergies to the supplement's ingredients. If you develop any allergic reaction symptoms, such as rash, itching, or swelling, stop using the product and get help from a doctor.
      • Long-Term Safety: Not much is known about the long-term safety of supplementing with calcium-aKG. As with any dietary supplement, it's crucial to use caution when using it for an extended period or in excess until further research is done.

      Sourcing Ca-AKG from Food

      Alpha-ketoglutarate is a naturally occurring source of amino acids, found in both plant and animal-based sources. As age increases, our body stops producing enough amounts of alpha-ketoglutarate required to the body. 

       

      • Meat: Pork and beef are red meat with calcium alpha-ketoglutarate. These meats support overall metabolism because they are high in proteins and other nutrients.
      • Fish: Salmon and trout are two fish species that also contain calcium alpha-ketoglutarate. Omega-3 fatty acids and other vital nutrients that support metabolic processes can be found in fish.
      • Dairy Products: Milk, cheese, and yogurt are dairy products that contain calcium alpha-ketoglutarate. These products contain calcium and other vitamins necessary for healthy metabolism in addition to this compound.
      • Eggs: One of the many uses for eggs is as a food source of calcium alpha-ketoglutarate. They are abundant in various nutrients and high-quality proteins that support overall metabolism.
      • Nuts and Seeds: Alpha-ketoglutarate is present in some nuts and seeds, including sunflower seeds and almonds. These foods offer a variety of essential nutrients, proteins, and healthy fats to support metabolic processes.
      • Leafy Greens: Alpha-ketoglutarate is present in certain vegetables, such as kale and spinach. A well-rounded, metabolically supportive diet is enhanced by the variety of vitamins, minerals, and antioxidants that these leafy greens provide.

      Including a range of these foods in your diet can help guarantee that you get enough calcium alpha-ketoglutarate naturally and other vital nutrients for metabolic support.

      Ca-AKG Supplements and its Benefits

      Discover the power of longevity with the Ca-AKG from the Decode Age. Our supplement, which is packed with Alpha Keto Glutarate, which has been shown to slow down biological ageing by up to five years, keeps your vitality levels sky-high. It enhances the natural energy balance of your body by supporting optimal metabolic function, thanks to the addition of calcium salts. Select Decode Age Ca-AKG, the secret to a more youthful and healthful existence.

      Benefits of Decode Age Ca-AKG

      • Enhanced Lifespan: The mechanism for lifespan extension was linked to the downregulation of mTOR kinase activity.
      • Neuroprotection: AKG plays an important role in the detoxification of ammonia in the brain by reducing the levels of lactate dehydrogenase, and malondialdehyde, and reducing oxidative stress.
      • Potent Antioxidant: AKG can prevent the brain from oxidative damage by increasing neuronal concentrations of antioxidative enzymes and quenching reactive oxygen species.
      • Anticancer: AKG regulates signalling pathways linked to oncogenesis and can reverse the metabolic response to hypoxia and restore oxidative phosphorylation in cancer cells
      • Skin Health: AKG can diminish skin wrinkle formation by increasing collagen production through a pathway that involves prolidase activation.
      • Osteoporosis: Some studies say that it showed protection against osteoporosis. Daily intake of oral Ca-AKG (6g AKG for 6 months) increased bone mass density by 1.6% from baseline (Filip et al., 2007).
      • Anti-inflammatory: Decreases inflammatory cytokines and suppresses chronic inflammation with improvements such as reduced hair loss and body weight maintenance.
      • Muscle recovery: Supports muscle recovery by removing nitrogen waste products from the body, which can cause muscle fatigue.
      • Energy metabolism: Involved in metabolism, specifically the citric acid cycle where the body converts food into energy. It also promotes energy production.
      • Anti-ageing: Reduces the inflammation caused by senescent cells (ageing cells) and slows down age-related DNA changes.

      Conclusion

      In conclusion, supplements containing calcium alpha-ketoglutarate (Ca-AKG) show promise for supporting metabolism, reducing inflammation, and possibly even delaying the ageing process. Ca-AKG is a versatile protein that plays a role in energy regulation, collagen synthesis, and DNA protection. For a complete understanding, more research is necessary, and caution is advised regarding possible side effects.

      FAQs

      1) What is calcium alpha-ketoglutarate used for?

      It is a type of calcium salt used to restore the concentration of calcium in the blood back to normal. It also helps in the synthesis of collagen, regulating energy and metabolism, and detoxifying the body.

      2) What is the function of Ca-AKG?

      It is a nitrogen scavenger and source of glutamate that helps in protein synthesis and inhibits protein degradation.

      3) Does calcium activate alpha-ketoglutarate dehydrogenase?

      Yes, Calcium activates alpha-ketoglutarate dehydrogenase through the reactions of the TCA enzymes- pyruvate dehydrogenase, isocitrate dehydrogenase, and α-ketoglutarate dehydrogenase complex. 

      4) Does calcium alpha-ketoglutarate work?

      It’s shown to extend lifespan, delay the onset of age-related conditions, reduce inflammation, and help in faster muscle recovery.

      5) What are the natural sources of Ca-AKG?

      The natural sources of Ca-AKG are meat, fish, dairy products, eggs, etc.,

       

      References

      Rhoads, T. W., & Anderson, R. M. (2020). Alpha-ketoglutarate, the metabolite that regulates aging in mice. Cell metabolism, 32(3), 323-325.

      https://doi.org/10.1016%2Fj.cmet.2020.08.009 

      Yuan, Y., Zhu, C., Wang, Y., Sun, J., Feng, J., Ma, Z., ... & Shu, G. (2022). α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling. Science advances, 8(18), eabn2879.

      https://doi.org/10.1126/sciadv.abn2879 

      Liu, S., He, L., & Yao, K. (2018). The antioxidative function of alpha-ketoglutarate and its applications. BioMed research international, 2018.

      https://doi.org/10.1155/2018/3408467 

      He, L., Li, H., Huang, N., Zhou, X., Tian, J., Li, T., ... & Yao, K. (2017). Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway. Oncotarget, 8(61), 102974.

      https://doi.org/10.18632%2Foncotarget.16875 

      Yang, F., Zhou, Z., Guo, M., & Zhou, Z. (2022). The study of skin hydration, anti‐wrinkles function improvement of anti‐aging cream with alpha‐ketoglutarate. Journal of Cosmetic Dermatology, 21(4), 1736-1743.

      https://doi.org/10.1111/jocd.14635 

      Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023). Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives. Experimental Gerontology, 175, 112154.

      https://doi.org/10.1016/j.exger.2023.112154 

      Gyanwali, B., Lim, Z. X., Soh, J., Lim, C., Guan, S. P., Goh, J., ... & Kennedy, B. K. (2022). Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends in Endocrinology & Metabolism, 33(2), 136-146.

      https://doi.org/10.1016/j.tem.2021.11.003 

      Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y., & Li, D. (2016). Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), 1.

      https://doi.org/10.4062%2Fbiomolther.2015.078 

      TeSlaa, T., Chaikovsky, A. C., Lipchina, I., Escobar, S. L., Hochedlinger, K., Huang, J., ... & Teitell, M. A. (2016). α-Ketoglutarate accelerates the initial differentiation of primed human pluripotent stem cells. Cell metabolism, 24(3), 485-493.

      http://dx.doi.org/10.1016/j.cmet.2016.07.002 



       

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