Do You Need To Take Best Longevity Supplements To Manage Inflammation?

Do You Need To Take Best Longevity Supplements To Manage Inflammation

      Have you ever wondered why some people age gracefully while others struggle with health challenges? The answer is more often simpler than not, sometimes it's how our lifestyle and diet take a toll on the cellular clocks. Inflammation is one of the same factors that accelerates ageing.

      Chronic inflammation, now commonly referred to as inflammaging, is a trending health concern that intensifies with age, leading to a spectrum of health problems. This prolonged inflammatory state wreaks havoc on our bodies, heightening the risk of diseases such as cardiovascular conditions, joint pain, and cognitive impairments. The good news is that we can counteract the adverse effects of inflammaging through various interventions. In this blog, we'll present you with actionable tips particularly the best longevity supplements to help you maintain healthy ageing.

      “Appearances can be deceiving! Despite feeling healthy, your body might be silently battling with chronic low-grade inflammation, slowly deteriorating your health like a hidden poison.”

      Lifestyle Interventions to Control Inflammaging

      Before we get into a list of anti-inflammatory supplements, addressing inflammation through lifestyle interventions such as an anti-inflammatory diet, exercise, stress and weight management is an important step towards longevity. By implementing these habits, individuals can reduce inflammation levels and control associated health ailments:

      Lifestyle Interventions to Control Inflammaging
      This hypothetical graph depicts inflammaging trends across different ages. The red line shows increased inflammation levels over time with age without any intervention. The blue line depicts inflammaging controlled by lifestyle interventions or supplementation. Inflammation level within the range of blue block in the graph is considered a healthy ageing response. This graph is not derived from real-life data and is for illustrative purposes only.
      1. Switch to a diet rich in antioxidants and polyphenols: Switching to an anti-inflammatory diet rich in antioxidants and polyphenols from regular food choices can help manage inflammaging. You should keep foods such as refined carbohydrates, high-fat dairy, fried foods, and red and processed meats at bay. Conversely, a Mediterranean diet, which includes fruits, fatty fish, leafy greens, nuts, olive oil, tomatoes, and whole grains, has been associated with lower inflammation levels. Even, vitamins for inflammation including vitamins A, B, C, D, E and K can be incorporated into your lifestyle.
      2. Exercise: Regular physical activity can help prevent or reverse the effects of diseases like type 2 diabetes and obesity. Research suggests that exercise regularly for a lifetime may prevent or delay the onset of immunosenescence. Older adults are advised to get at least 2.5 hours of moderate-intensity exercise per week, along with muscle-strengthening activities for at least 2 days. (Turner, 2016)
      3. Gut Microbiome: As we age, microbial dysbiosis can lead to a less resilient gut ecosystem, making it more susceptible to inflammation. The decline in beneficial bacteria that produce anti-inflammatory metabolites, such as butyrate, further exacerbates this issue.

        Inflammation promotes the growth of harmful bacteria, which, in turn, displaces beneficial bacteria, leading to lower production of anti-inflammatory metabolites like SCFAs. This reduction in SCFAs then allows inflammation to escalate, creating a cycle that perpetuates inflammaging. Thus, you can incorporate various changes to balance the gut microbiome. 

        Bacteriodetes and Firmicutes constitute 90% of gut bacteria in healthy gut biome while the shift with ageing causing dysbiosis can make place for opportunistic bacteria causing inflammation.
      4. Stress and Weight Management: Chronic stress can trigger the release of pro-inflammatory cytokines, contributing to inflammaging. Practices like mindfulness meditation, spending time with supportive loved ones, engaging in enjoyable activities, and deep breathing exercises can help reduce stress levels.
        Obesity is associated with low-grade inflammation, and excess body fat can contribute to inflammaging. Maintaining a moderate weight through a healthy diet and regular exercise can help manage inflammation levels.

      List of Best Longevity Supplements To Reduce Inflammation In The Body

      Could a simple lifestyle tweak be the answer to beating inflammation? While adopting an anti-inflammatory diet, exercising regularly, managing stress, and prioritising sleep is essential, incorporating anti-inflammatory supplements can be a game-changer. These supplements act like a superhero squad, armed with antioxidants or senolytics that clear out senescent cells, ultimately reducing chronic inflammation.

      Senolytic Supplements

      1. Fisetin: Fisetin supplement, a powerful senolytic supplement with its polyphenolic structure demonstrates significant anti-inflammatory properties. It works by suppressing JNK phosphorylation and NF-κB activation, crucial pathways involved in inflammation. Studies show that it reduces levels of pro-inflammatory factors like IL-6 and TNF-α when co-treated with lipopolysaccharides.

        This suppression suggests that fisetin promotes autophagy which is essential for anti-inflammatory effects. By targeting senescent cells and reducing chronic inflammation, fisetin holds promise as an anti-inflammatory supplement for mitigating age-related diseases. (Sun et al., 2021)

      2. Quercetin: A strong anti-inflammatory effect can be seen in quercetin making it a preferable choice of senolytic supplement for inflammation. Studies show that quercetin lowers IL-6, NF-κB, and nitric oxide production levels. It also reduces IgE levels and inflammation, as evidenced by histological analysis and ear thickness measurements. It suppresses the production of cyclooxygenase (COX) and lipoxygenase (LOX), enzymes known for driving inflammation. (Li et al., 2016)

        It inhibits the growth of IL-8-induced LPS and suppresses LPS-mediated TNF-α production in macrophages. By decreasing TNF-α and IL-1α levels, high quality quercetin reduces apoptotic neuronal cell death caused by activated microglia.


      1. Trans- Resveratrol: Trans-resveratrol, a potent antioxidant is known for its anti-inflammatory properties. Resveratrol inhibits lymphocytes from producing IL-2 and interferon-gamma (IFN-γ), as well as macrophages from producing tumour necrosis factor-alpha (TNF-α) or IL-12.

        In addition to these effects, it reduces the production of reactive oxygen species (ROS) and nitric oxide (NO), which are key contributors to inflammation. It also inhibits COX-1 and COX-2, i.e., inflammatory enzymes, further decreasing inflammation. By activating sirtuin-1 (Sirt-1), it helps regulate inflammation. SIRT1 activation leads to the inhibition of phospho-p38 MAPK and reduces NF-κB p65 activity. (Meng et al., 2021)

        If you want to make the most out of supplementation, it’s important to choose pure trans-resveratrol over regular resveratrol as it ensures a higher bioavailability and potency.

      2. Trans-Pterostilbene: Trans-pterostilbene, an antioxidant and potent anti-inflammatory supplement, has been shown to exhibit remarkable effects in reducing inflammation. The study revealed that pterostilbene significantly decreased the secretion of inflammatory factors such as IL-6 and TNF-α. It also reduced the expression of proinflammatory genes. (Surien et al., 2023)

        Furthermore, it decreased the migratory ability of macrophages towards adipocytes, indicating its potential to mitigate inflammation-related conditions. Its ability to lower NF-κB and COX-2 expression, downregulate TNF-α and IL-1β levels, and reduce inflammation in conditions like atopic dermatitis. This makes trans-pterostilbene a compelling choice for those seeking an effective supplement.


      Inflammation, often a stealthy culprit, lurks within us, quietly building until it triggers more serious health issues like chronic pain, cardiovascular diseases, or metabolic disorders. Despite its silent nature, inflammation can be managed effectively through a combination of lifestyle changes and dietary adjustments.

      Regular exercise plays a crucial role in reducing inflammation by promoting circulation and reducing excess fat, which can produce inflammatory substances. Additionally, a balanced diet rich in anti-inflammatory foods such as fruits, vegetables, nuts, and fish can significantly mitigate the body's inflammatory response. Cultivating a healthy gut microbiome is another vital factor, as the gut's health directly influences the body's inflammatory processes. Reducing stress through mindfulness practices, yoga, or other relaxation techniques is also essential, as stress is a well-known trigger for inflammation.

      Moreover, the use of supplements can offer additional support. Senolytic duo, particularly containing high-quality quercetin and fisetin supplements, have shown promise in targeting and eliminating senescent cells, which contribute to inflammation. Antioxidants like trans-resveratrol and trans-pterostilbene act as powerful agents against oxidative stress and inflammation. Together, these lifestyle changes and supplements can act as mighty warriors, slashing through inflammation, promoting overall health and reducing the risk of inflammation-related diseases.



      Is immunosenescence influenced by our lifetime “dose” of exercise?
      (Turner, J. E. (2016). Is immunosenescence influenced by our lifetime “dose” of exercise? Biogerontology, 17(3), 581–602.)

      Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264
      (Sun, Y., Qin, H., Zhang, H., Feng, X., Yang, L., Hou, X., & Chen, J. (2021). Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. Food & Nutrition Research, 65.)

      Quercetin, inflammation and immunity
      (Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M. T., Wang, S., Liu, H., & Yin, Y. (2016). Quercetin, inflammation and immunity. Nutrients, 8(3), 167.)

      Anti-Inflammatory action and mechanisms of resveratrol
      (Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L., & He, J. (2021). Anti-Inflammatory action and mechanisms of resveratrol. Molecules/Molecules Online/Molecules Annual, 26(1), 229.)

      Anti-inflammatory and anti-cancer potential of pterostilbene: A review.
      (Surien, O., Masre, S. F., Basri, D. F., & Ghazali, A. R. (2023). Anti-inflammatory and anti-cancer potential of pterostilbene: A review. Asian Pacific Journal of Tropical Biomedicine/Asian Pacific Journal of Tropical Biomedicine, 13(12), 497–506.)


      1. What are the best vitamins for inflammation?
        The best diet includes foods rich in vitamins for inflammation. Vitamin A regulates immune response, while B vitamins lower inflammatory markers. Vitamin C fights free radicals, vitamin D reduces inflammation, and vitamin E has anti-inflammatory effects. Vitamin K reduces inflammatory markers and aids in blood clotting and bone health.

      2. Are there any supplements to reduce inflammation in the body?
        Yes, there are! Consider the best longevity supplements, including antioxidant and senolytic supplements. Antioxidants reduce inflammatory cytokines and gene expression, while senolytics minimise senescent cells, easing inflammaging and supporting tissue health.

      3. Does fisetin reduce inflammation?
        Yes, fisetin supplement demonstrates significant anti-inflammatory properties. It works by suppressing JNK phosphorylation and NF-κB activation, crucial pathways in inflammation. Studies show it reduces levels of pro-inflammatory cytokines suggesting it promotes autophagy essential for anti-inflammatory effects.

      4. Is trans-resveratrol anti-inflammatory?
        Yes, pure trans-resveratrol is anti-inflammatory. It inhibits the production of inflammatory cytokines like IL-2, IFN-γ, TNF-α, and IL-12. Additionally, it reduces ROS and NO production, key contributors to inflammation, and activates Sirt-1, which helps regulate inflammation.

      5. Is there any supplement bundle with anti-inflammatory properties in India?
        Yes, the Decode Age Inflammation Management Bundle in India combines the synergistic effects of SeneVit, a senolytic blend, and ResVit, an antioxidant blend, to help ease chronic inflammation caused by aging, intense exercise, or health conditions.

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