Your A to Z Guide for Understanding Longevity Supplements

Longevity supplements are gaining popularity as people seek to enhance their health and extend their lifespan. These supplements offer essential nutrients and compounds that may promote overall well-being. However, they are not standalone solutions but should complement a balanced diet and a healthy lifestyle. Informed decisions are crucial when choosing supplements, considering ingredients, and consulting with healthcare professionals. This trend aligns with geroscience's goal to delay ageing and increase a healthy lifespan, emphasising the potential "longevity dividend." As nutraceutical  advancements like calorie restriction mimetics and senolytics emerge, informed use of supplements becomes integral to a holistic health strategy. (Vaiserman & Lushchak, 2017) 

The Science Behind Longevity Supplements 

Longevity supplements are dietary supplements formulated with ingredients believed to support healthy ageing and increase lifespan. These supplements often contain antioxidants, vitamins, minerals, senolytics, and other nutrients that promote overall health and well-being. The purpose of these supplements is to provide nutrient-rich support that may help delay the onset of age-associated decline, improve cognitive function, enhance immune system function, etc. Scientifically-backed supplements have undergone rigorous testing and research to validate their claims and demonstrate their potential benefits for longevity and overall health. Here is a list of science backed longevity supplements for healthy ageing:

NMN (Nicotinamide Mononucleotide)

Nicotinamide mononucleotide (NMN) plays a crucial role as a precursor to NAD+, a vital molecule required for energy, metabolism, DNA repair, and cell survival. As NAD+ levels decline with age, supplementation with NMN offers a potential way to increase NAD+ levels in the body. Moreover, studies suggest NMN supplementation may be more efficient at raising NAD+ levels and serving as a SIRT activator. Research shows promise for improving insulin sensitivity, enhancing energy metabolism, and potentially preventing age-related decline in mitochondria.

Spermidine

Spermidine, a natural polyamine found in cells, is vital for cellular health. It mimics fasting by promoting autophagy  and protecting DNA and cells. Research suggests it triggers autophagosome formation, cleansing cellular debris in various organisms. This "cellular housekeeping" rejuvenates cells, improving mitochondrial function and reducing inflammation, potentially extending lifespan and overall health.

TMG (Trimethylglycine)

TMG, also known as trimethyl glycine or betaine anhydrous, is a molecule that provides methyl groups (-CH3) for vital functions, playing crucial roles in DNA repair, gene expression, protein function, and metabolism. By donating methyl groups, TMG aids in converting the amino acid homocysteine to methionine, potentially lowering the risk of heart disease. Additionally, TMG supports elevated athletic performance and  digestive health. Ongoing research indicates that TMG may also support liver function and cognitive function in older adults.

Trans-Resveratrol

Trans-Resveratrol, a potent antioxidant found in grapes, acts as a shield by neutralising free radicals and protecting cells from oxidative damage. Ongoing research investigates its potential lifespan benefits in humans, while trans-resveratrol shows promise for heart health by potentially reducing blood pressure and enhancing blood flow. Moreover, its anti-inflammatory properties may offer benefits for conditions such as arthritis and managing blood sugar levels. It also promotes calorie efficiency, modulates epigenetic changes, and addresses age-related brain decline.

Calcium Alpha-Ketoglutarate (Ca-AKG)

Calcium Alpha-Ketoglutarate (Ca-AKG) is a molecule gaining interest for its potential to enhance cellular health and strengthen bones. It functions within the Krebs cycle, readily donating a fragment for energy and converting it into other key compounds such as glutamine and glutamate, which may enhance cellular energy efficiency. While research is ongoing, a study found that Ca-AKG supplementation significantly reduced biological age, delayed the onset of age-related diseases, and improved muscle function.

Fisetin

Fisetin, a natural compound found in strawberries,  is a potent senolytic activator. Research indicates that fisetin is a powerful antioxidant, combating harmful free radicals. It may also help clear out senescent cells that accumulate with age and contribute to ageing. Moreover, fisetin shows promise in supporting memory, protecting brain function, and potentially enhancing cellular stress resistance, thereby potentially slowing down age-related decline.

Quercetin

Quercetin, a natural antioxidant and anti-inflammatory compound found in fruits, is currently being studied for its potential to promote longevity. It acts as a shield against free radicals, eliminates senescent cells, and relieves allergies. Additionally, quercetin combats chronic inflammation, a low-grade inflammation linked to many age-related problems. By slowing cellular decline, decreasing the risk of chronic diseases, and promoting overall cellular health.

Trans-Pterostilbene

Trans-Pterostilbene, found in blueberries, acts as an antioxidant with potential benefits for longevity, heart health, and brain function. Its high bioavailability and prolonged effects  offer enhanced protection against cellular damage and support various longevity-related processes, including antioxidant and anti-inflammatory actions. Moreover, it promotes sirtuin activation and enhances calorie efficiency. Studies suggest it could enhance mitochondrial function and resilience, potentially delaying age-related decline.

Factors to Consider When Choosing Supplements

When choosing longevity supplements, it's essential to consider several factors to ensure they are safe, effective, and suitable for your needs. Here are some key factors to consider:

Safety Profile

Evaluate the safety profile of the supplement, including potential side effects, interactions with medications, and contraindications for certain populations (e.g., pregnant women and individuals with pre-existing medical conditions). Consult with a healthcare professional before starting any new supplement regimen, especially if you have underlying health concerns.

Quality and Purity 

Choose supplements from reputable brands that adhere to good manufacturing practices (GMP) and have undergone third-party testing for quality and purity. This ensures that the supplements contain the stated ingredients in the correct dosage and are free from contaminants.

Scientific Evidence

Look for supplements that are supported by scientific evidence demonstrating their efficacy in promoting longevity and overall health. Consider reputable sources such as peer-reviewed studies, clinical trials, and meta-analyses to assess the strength of the evidence.

Bioavailability

Consider the bioavailability of the supplement, which refers to the extent to which the nutrients are absorbed and utilized by the body. Look for supplements with ingredients in forms that are easily absorbed and in highly bioavailable forms.

Dosage and Form

Pay attention to the dosage and form of the supplement. Some nutrients may require higher doses to be effective, while others may be more potent in specific forms. Choose supplements that provide the recommended dosage and are available in convenient forms (e.g., capsules or tablets).

Personal Health Goals

Consider your individual health goals and needs when choosing longevity supplements. Tailor your supplement regimen to address specific areas of concern, such as cardiovascular health, cognitive function, immune support, or joint health.

Lifestyle Factors

Consider your lifestyle factors, such as diet, exercise habits, stress levels, and sleep quality, when selecting supplements. Supplements should complement a healthy lifestyle and dietary habits rather than serve as a substitute for poor health practices.

Ingredients

Look for supplements with ingredients backed by scientific research on their efficacy in promoting longevity and overall health. Common ingredients may include antioxidants, vitamins, minerals, and omega-3 fatty acids.

Long-Term Use 

Consider the potential long-term effects of the supplement on your health and well-being. Choose supplements that are suitable for long-term use and incorporate them into a sustainable wellness routine for lasting benefits.

Cost-Effectiveness

Consider the cost-effectiveness of the supplement in terms of its quality and efficacy. While it's essential to invest in high-quality supplements, you should also compare prices and consider whether the benefits justify the cost.

Summary

 

Supplemnets	Benefits	Consumption	Age groups
NMN (250mg,500mg,1000mg and NMN 100 powder)	NAD+ Booster Regulates Circadian Rhythm Promotes DNA Repair	250mg &500mg - Take one capsule after your first morning meal. If you're using NMN 1000, take two capsules after breakfast. NMN 100 powder: Best taken on an empty stomach for optimal absorption. Let it dissolve under your tongue for quick absorption. Don't use hot drinks, as heat reduces NMN's effectiveness. Avoid taking NMN after 3pm.	Ages 18-30: Take 250mg NMN or Decode Age LongeVit. Ages 31-50: Opt for a 500mg dose. Age 50 and above: recommended dosage is 1000mg. Athletes aged 18-30: benefit from a 500mg dosage. Athletes aged 30 and above: go for a 1000mg dosage.
Spermidine	Enhances Neuroprotection Promotes Autophagy Enhances Mitochondrial Function	Start with one capsule daily, preferably with a meal. After assessing your tolerance, increase to two capsules daily - one in the morning and one in the evening.	Adults (18-50): Start with one capsule daily. 50+ years: Start with one; increase to two capsules daily.
TMG	Improves Physical Performance Advanced Methylation Support Elevates Cardiovascular Health	Take 1 capsule in the morning after your breakfast or lunch.	-
Trans-Resveratrol (250mg,500mg)	Diminishes Oxidative Stress Improves Blood Sugar Levels Reduces Age-related Weight Gain	Take trans-resveratrol; it's best to take it after dinner in the evening. If you're pairing it with NMN, take trans-resveratrol in the morning.	Adults can take 250mg - 1500mg of Trans Resveratrol daily. Start with a low dose, adjust as needed, and always listen to your body's response.
Ca-AKG	Improves Energy Metabolism Enhances Bone and Muscle Health Sharpens Cognition	Take 1 capsule in the morning after your breakfast or lunch. It is advisable to avoid taking Ca-AKG if you have kidney problems.	-
Fisetin	Clears away senescent cells Reduces Inflammation Rejuvenates Cells	Take 1 capsule after dinner.	-
Quercetin	Promotes Healthy Inflammatory Response Relieves Allergies Eliminates Senescent Cells	Take one capsule at mid-day.	-
Trans-Pterostilbene	Potent Antioxidant Regulates Blood Glucose Levels Activates Longevity Pathways	Take one Trans-Pterostilbene capsule daily after dinner. If consuming with NMN, take 1 capsule of Trans-Pterostilbene with NMN in the morning after breakfast or lunch.	-

Suitable for individuals with: high blood sugar, hypertension, or high blood pressure.

Before starting these supplements, it's crucial to consult with your physician, particularly if you have bleeding disorders, are taking blood-thinning medications, or if you are pregnant or breastfeeding. These supplements are not recommended for individuals under 18 years of age.

Reference:

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives
(Vaiserman, A., Lushchak, O. Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives. J Transl Med 15, 160 (2017).)

Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
(Nadeeshani, H., Li, J., Ying, T., Zhang, B., & Lu, J. (2022). Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns. Journal of Advanced Research, 37, 267-278.)

Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?
(Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019). Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy, 15(1), 165-168.)

Betaine in Inflammation: Mechanistic Aspects and Applications
(Zhao, G., He, F., Wu, C., Li, P., Li, N., Deng, J., Zhu, G., Ren, W., & Peng, Y. (2018). Betaine in Inflammation: Mechanistic Aspects and Applications. Frontiers in Immunology, 9.)

Antiaging effects of dietary supplements and natural products
(Gao, L., Liu, X., Luo, X., Lou, X., Li, P., Li, X., & Liu, X. (2023). Antiaging effects of dietary supplements and natural products. Frontiers in Pharmacology, 14.)

Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice
(Rhoads, T. W., & Anderson, R. M. (2020). Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice. Cell Metabolism, 32(3), 323.)

Biological Activities of Stilbenoids
(Akinwumi, B. C., Bordun, A. M., & Anderson, H. D. (2018). Biological Activities of Stilbenoids. International Journal of Molecular Sciences, 19(3).)

FAQs

1) What supplements are good for delaying ageing?

To slow down ageing, incorporating certain supplements alongside a healthy diet and lifestyle can be beneficial. Compounds like NMN, Spermidine, TMG, Fisetin, Resveratrol and more have demonstrated age-supportive effects. These supplements can aid in slowing down the ageing process and promoting a longer, healthier life.

2) What is the best age to start taking anti-ageing supplements?

The best age to start taking anti-ageing supplements is typically in the late 20s or early 30s. Beginning at this stage allows you to address ageing symptoms before they become pronounced. Moreover, by starting early, you can effectively slow down the ageing process. Supplements serve as preventive measures for age-related decline.

3) What are the three types of ageing?

The three types of ageing are biological ageing, psychological ageing, and chronological ageing. Biological ageing encompasses natural changes in the body over time, affecting organs, senses, and overall physical health. Psychological ageing relates to changes in behaviour, cognition, and emotional responses influenced by brain function and life experiences. Chronological ageing refers to the passage of time and the numerical age of an individual, serving as a marker for tracking and understanding various life stages and milestones.

4) Does NMN heal the body?

NMN supplementation has shown promising results in healing the body. Studies have revealed that supplementation with NMN increases NAD+ biosynthesis, which plays a crucial role in various cellular processes. Additionally, NMN has been found to suppress age-related adipose tissue inflammation, enhance insulin secretion and insulin action, improve mitochondrial function, and enhance neuronal function in the brain. These combined effects suggest that NMN can indeed contribute to the healing and rejuvenation of the body.

5) What are GMP-certified supplements?

GMP (good manufacturing practice)-certified supplements follow strict rules set by the FDA to ensure they're safe and reliable. These rules cover everything from cleanliness to how they're made and tested. By sticking to these rules, manufacturers guarantee that their supplements are safe, potent, and accurately labelled. When you see a GMP certification, you can trust that the supplement meets high quality standards, giving you confidence in what you're buying. Decode Age supplements are GMP certified.

6) Are Decode Age supplements backed by scientific research?

Certainly, Decode Age supplements have undergone rigorous scientific research to support their efficacy and safety. Numerous studies and clinical trials have been conducted to validate the effectiveness of their formulations. These studies provide robust evidence of the benefits offered by Decode Age supplements, ensuring consumers can trust in their quality and reliability.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.