Regular NMN Versus Liposomal NMN: Key Differences Explored

As individuals age, they become susceptible to various age-related diseases. Nicotinamide Mononucleotide (NMN) is a NAD+ supplement, that helps increase energy levels, enhance mitochondrial function, and delay signs of ageing, leading to healthy ageing. While regular NMN exists, liposomal NMN, like Decode Age's NMN powder, offers enhanced absorption. This blog explains the differences between regular and liposomal NMN, including Decode Age's NMN, and its impact on longevity.

What are liposomes?

Liposomes are tiny spherical vesicles of lipid bilayers surrounded by an aqueous core. They're formed when lipid molecules disperse in water. These structures are vital in drug delivery, as they can encapsulate drugs and transport them to specific cells. When administered, liposomes fuse with cell membranes, releasing their contents inside. This targeted delivery reduces side effects and enhances treatment effectiveness.

Importance of Liposomes in Ageing

In the context of ageing, liposomes hold considerable importance in several aspects: (Lamichhane et al., 2018b)

Application	Description
Anti-ageing Drug Delivery	Liposomal formulations enhance the stability and bioavailability of compounds like NMN, improving efficacy in anti-ageing.
Skin Rejuvenation	Liposomes deliver antioxidants and moisturizers to skin cells, rejuvenating ageing skin, reducing wrinkles, and improving texture.
Disease Management	Targeted delivery via liposomes enhances therapeutic effects for age-related diseases (cancer, cardiovascular, neurodegenerative) while minimizing toxicity.
Nutrient Delivery	Carriers for essential nutrients and vitamins, improving stability and absorption for combating age-related deficiencies.

What is Liposomal NMN?

Liposomal NMN (Nicotinamide Mononucleotide) refers to a specialized formulation of NMN where the compound is encapsulated within lipid bilayers called liposomes. These liposomes act as protective carriers, safeguarding NMN from degradation in the digestive system and promoting its efficient absorption into the bloodstream. Liposomal NMN is engineered to mimic the natural cell-to-cell exchange mechanism of NMjN, enhancing its bioavailability and efficacy in supporting cellular health and metabolic functions.

 Efficacy and Benefits

The efficacy and benefits of both regular and liposomal NMN are given below in the table:

Characteristics	NMN Capsules (Shade, 2020b)	Liposomal NMN
Absorption	While NMN supplements may undergo some degradation in the gastrointestinal tract, their bioavailability remains considerable, offering significant potential benefits for cellular health and longevity.	Offers superior bioavailability and absorption due to liposomal encapsulation, protecting NMN from degradation in the gastrointestinal tract
Effectiveness	Effective, but may require higher doses for desired effects	More effective with smaller doses, yielding stronger and more rapid effects compared to regular NMN supplements
Protection	Not protected against degradation in the gastrointestinal tract	Shielded from harsh gastrointestinal environments, ensuring integrity until reaching the bloodstream
Synergy	Can be taken alone or with other dietary supplements	Can be paired with other liposomal formulations for synergistic effects, enhancing overall effectiveness
Cost	Standard pricing for NMN supplements	May be more expensive due to enhanced formulation and effectiveness
Convenience	Available in various forms (capsules, powder, etc.)	Available in various forms (capsules, powder, etc.), with the added benefit of superior absorption
Recommended Dosage	Varies depending on age and individual needs	Generally smaller doses are recommended for optimal effectiveness due to improved absorption
Potential Side Effects	Similar to other NMN supplements	Similar to other NMN supplements, with the potential for reduced gastrointestinal side effects due to enhanced absorption
Overall Effectiveness	Effective for promoting cellular health and longevity	More effective in delivering NMN to cells, potentially leading to enhanced cellular health and anti-ageing benefits

Considerations for Choosing Between Regular and Liposomal NMN

The factors influencing the choice of a supplement include:

• Bioavailability: Liposomal technology boosts nutrient absorption and utilization, delivering superior bioavailability over regular NMN for optimal cellular benefit.
• Convenience: Ease of use, dosage form, and dosing frequency impact convenience. Liposomal supplements, with their smaller doses and better absorption, offer a more convenient, less frequent dosing schedule.
• Cost: Considering cost-effectiveness, liposomal supplements, despite their higher price, offer greater bioavailability and efficiency, possibly requiring lower doses than traditional supplements. Evaluating their value is crucial.
• Safety and Purity: Safety and purity are crucial for supplements. Liposomal versions need thorough testing for purity and quality, plus a review of any possible side effects or interactions with other medications.
• Effectiveness: Ultimately, a supplement's success hinges on its efficacy. Liposomal options, with their enhanced absorption and potential health benefits, need scientific backing and clinical validation.
• Individual Preferences and Needs: Personal preferences, dietary needs, and health goals significantly influence supplement selection, including taste and texture considerations.

How to choose NMN?

 

Understanding different factors that contribute to selecting the correct NMN supplementation is crucial for maximizing its potential benefits. Here's an analysis of the key considerations:

Delivery Method

NMN supplements come in different forms, such as capsules, powder, chewable tablets, sublingual formulations, intranasal sprays, transdermal creams, serums, and liposomal formulations. Among these options, oral supplementation of NMN in powder or capsule form is the only method clinically tested for safety and efficacy. While other delivery methods like sublingual or intranasal administration may seem convenient, their safety and effectiveness haven't been sufficiently researched. Therefore, it's crucial to prioritize proven delivery methods until further research confirms the safety and efficacy of alternative administration routes.

Dosage

Determining the right NMN dosage is vital for desired results without adverse effects. Dosage varies based on factors like age and health. Consult healthcare professionals or reputable manufacturers' guidelines for safe use. Seek expert advice to optimize NMN benefits and minimize risks.

Quality and Purity

Selecting a high-quality NMN supplement is crucial for effective and safe anti-ageing benefits. Prioritize reputable companies with strict quality control standards and third-party testing for purity and potency. Look for supplements free from fillers and additives to minimize health risks. By choosing wisely, you can maximize NMN's benefits while ensuring your well-being.

Complementary Ingredients

NMN supplements often incorporate complementary ingredients like NR, resveratrol, quercetin, and pterostilbene to enhance NAD+ metabolism and combat ageing. These compounds work synergistically with NMN, promoting cellular health and reducing oxidative stress. Antioxidants, vitamins, and minerals further support overall well-being. Together, these ingredients aim to provide comprehensive anti-ageing support and promote overall health.

A New Trend in NMN Delivery: NAD+ IV Therapy

NAD+ IV therapy is a cutting-edge approach to wellness that involves the direct administration of Nicotinamide Adenine Dinucleotide (NAD+) into the bloodstream. This therapy offers unique advantages over oral supplementation, ensuring maximum bioavailability of NAD+ and optimal absorption by the body.

Benefits

The benefits of NAD+ IV Therapy are:

• Enhances brain function and slows cognitive decline.
• Boosts energy levels and combats fatigue.
• Supports metabolism for healthy weight and blood sugar.
• Promotes cell regeneration for faster recovery and health.

Suitable Candidates

• Individuals experiencing cognitive decline, chronic fatigue, or age-related illnesses can benefit from NAD+ IV therapy.
• Athletes seeking performance enhancement and accelerated recovery can also find value in this therapy.
• Those battling substance addictions may find NAD+ therapy helpful in repairing brain cells and reducing withdrawal symptoms.
• Individuals looking to delay the ageing process and improve overall wellness can incorporate NAD+ IV therapy into their health regimen.

Best Liposomal NMN Supplement in India

Decode Age's Sublingual Liposomal NMN Powder Uthever offers a comprehensive solution for individuals seeking to optimize their health and well-being. With a range of benefits including enhanced oral health, increased NAD+ levels, boosted energy, and support for graceful ageing, this supplement addresses multiple facets of wellness. Additionally, it aims to improve cognition, promote eye health, enhance metabolism, restore DNA, and provide support for cellular energy production. By incorporating this NMN powder into their daily routine, individuals can take proactive steps towards maintaining their overall health and vitality.

Dosage Recommendations

• Ages 18-30: Take 250mg NMN.
• Ages 31-50: Opt for a 500mg dose.
• Age 50 and above: Recommended dosage is 1000mg.
• Athletes Aged 18-30: Benefit from a 500mg dosage.
• Athletes Aged 30 and Above: Go for a 1000mg dosage.

Usage Instructions

• Start with a Low Dosage: Begin by taking a low dosage of NMN Powder, ideally one scoop daily.
• Gradual Increase: Gradually increase the dosage as your body adjusts, following your healthcare provider's advice.
• Administration Options: You can mix it in water, or food, or place it under your tongue for sublingual absorption.
• Optimal Timing: Consume NMN Powder ideally on an empty stomach in the morning for enhanced absorption.

Conclusion

In summary, the development of NMN supplements, particularly liposomal NMN, offers promising avenues for anti-ageing and health enhancement. Liposomal NMN stands out for its superior absorption and bioavailability, potentially providing more effective support against ageing effects compared to regular NMN. Key considerations in choosing an NMN supplement include delivery method, dosage, quality, and the presence of complementary ingredients. Furthermore, NAD+ IV therapy offers a direct approach with unique benefits for ageing-related concerns, complementing NMN supplementation. Making an informed choice between these options, based on scientific evidence and individual health goals, is crucial for optimizing health and longevity outcomes.

References

Liposomes: clinical applications and potential for image-guided drug delivery.
(Lamichhane, N., Udayakumar, T. S., D’Souza, W. D., Simone, C. B., Raghavan, S. R., Polf, J., & Mahmood, J. (2018). Liposomes: clinical applications and potential for image-guided drug delivery. Molecules, 2018.)

The science behind NMN–A stable, reliable NAD+ activator and anti-aging molecule. 
(Shade, C. (2020). The science behind NMN–A stable, reliable NAD+ activator and anti-aging molecule. Integrative Medicine: A Clinician's Journal, 2020.)

FAQs

1) What is the difference between liposomal and regular NMN?

Liposomal NMN differs from regular NMN in its delivery method and absorption efficiency. Liposomal NMN is encapsulated in lipid molecules, enhancing its bioavailability and absorption rates compared to regular NMN supplements. This encapsulation protects NMN from degradation in the gastrointestinal tract, ensuring a higher proportion reaches systemic circulation for optimal health support. As a result, liposomal NMN may require smaller doses to achieve desired effects compared to regular NMN.

2) How much liposomal NMN should I take?

The recommended dosage of liposomal NMN typically ranges from 250 to 1000mg per day, depending on factors such as age and health condition. For individuals aged 18-30, a starting dose of 250mg is recommended, while those aged 31-50 may opt for 500mg. Individuals over 50 years old or athletes may consider a dosage of 1000mg. It's crucial to consult with a healthcare provider for personalized dosage recommendations.

3) How do you take liposomal NMN?

To take liposomal NMN, follow the recommended dosage instructions provided by the manufacturer or your healthcare provider. Typically, liposomal NMN is taken orally by placing the desired dose under the tongue and allowing it to dissolve for rapid absorption into the bloodstream. Alternatively, it can be mixed with cold drinks or food. It's important to take liposomal NMN on an empty stomach for optimal absorption and effectiveness.

4) What is the best liposomal NMN?

The best liposomal NMN supplement is Decode Age's Sublingual Liposomal NMN Powder Uthever. This premium product offers superior wellness benefits with its pharmaceutical-grade formulation. With enhanced bioavailability, it ensures efficient absorption for optimal health support, targeting energy enhancement, cognitive function improvement, and healthy ageing promotion. Its comprehensive benefits, flexible dosage recommendations, and versatile consumption options make it a standout choice for individuals prioritizing maximum effectiveness and convenience in NMN supplementation.

5) What does NAD+ therapy do?

NAD+ therapy involves administering Nicotinamide Adenine Dinucleotide (NAD+) directly into the bloodstream through intravenous infusion. NAD+ therapy aims to increase NAD+ levels in the body, which plays a crucial role in cellular energy production, metabolism, and DNA repair. By replenishing NAD+ levels, this therapy may slow cognitive decline, boost energy levels, promote cellular regeneration, reduce inflammation, and improve overall well-being.

6) How do I choose the right NMN supplement?

When selecting an NMN supplement, consider Decode Age's offerings for superior wellness. Decode Age's Sublingual Liposomal NMN Powder Uthever stands out with its pharmaceutical-grade quality and enhanced bioavailability. Tailored dosage recommendations cater to different age groups and athletes, ensuring personalized supplementation. With versatile consumption options and a focus on optimal absorption, Decode Age's NMN supplement offers a convenient and effective solution for supporting overall health and well-being.