We are going to live beyond 100

The science of longevity is constantly evolving every single day, every single second.

The average life expectancy of Indians has increased exponentially over the past two centuries, while the fertility rate is declining at an alarming rate. This change in demography is leading us to the inevitable Silver Tsunami.

Silver tsunami, founder, founders life, startup, startuplife, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing

Silver Tsunami

“When we look at this trend from a demographic perspective, we can conclude that the rate at which people are entering the retirement stage will exponentially outpace the rate at which individuals enter the workforce. The seesaw is evidently leaning towards the onset of the Silver Tsunami, in fact, it has already been done in countries like Japan.” Darshit Patel

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14 Hallmarks of Ageing

Scientifically proven root causes of why your body age.

Aging Hallmark - Genomic Instability
01

Genomic Instability

Various endogenous or exogenous agents cause a variety of genetic lesions. Our body has multiple mechanisms to repair these. However, excess DNA damage or insufficient DNA repair favours the ageing process.

Telomere Attrition Cause of Aging
02

Telomere Attrition

Ageing is usually accompanied by telomere attrition. Pathological dysfunction of DNA accelerates ageing. Experimental stimulation of telomerase was shown to delay ageing.

Aging Hallmar - Epigenetic Regulation
03

Epigenetic Regulation

Ageing is associated with epigenetic changes such as alterations in DNA methylation patterns, post-translational modification of histones and chromatin remodelling. Loss of function of epigenetically relevant enzymes reduces longevity whereas the gain of their function extends longevity.

Aging Hallmark - Loss of Proteostasis
04

Loss of Proteostasis

Ageing is associated with impaired protein homeostasis. Endogenous or exogenous stress leads to unfolding or misfolding of proteins. These are either repaired or destroyed through various pathways. A failure of these mechanisms lead to accumulation or aggregation of damaged proteins. Aggregation of damaged proteins lead to various age-related pathologies.

Aging Hallmark - Deregulated Nutrient Sensing
05

Deregulated nutrient sensing

The four pathways that mainly control metabolism are Insulin/IGF-1 pathway, mTOR pathway, AMPK and Sirtuins. Genetic mutations that alter the functioning of these pathways is linked to longevity. Anabolic signalling hastens ageing whereas reduced nutritional signalling facilitates longevity.

Aging Hallmark - Mitochuondrial Dysfunction
06

Mitochondrial dysfunction

Mitochondrial functioning has significant implications on the ageing process. Mitochondrial dysfunction brought on by various mechanisms, accelerates ageing through different means.

Aging Hallmark - Cellular Senescence
07

Cellular Senescence

Cellular senescence is a stable arrest of cell cycle in normal cells triggered by various intrinsic and extrinsic stimuli. As the organisms age, senescent cells accumulate due to widespread damage and insufficient clearing. This has deleterious impact on tissue homeostasis and contributes to ageing.

Aging Hallmark - Stem Cell Exhaustion
08

Stem Cell Exhaustion

Decline of stem cells occur as a consequence of various types of ageing-related cellular damages. Recent research shows that stem cell rejuvenation may be a promising approach to reverse ageing.

Aging Hallmark - Altered Intercellular Communication
09

Altered Intercellular Communication

Ageing is accompanied by changes in intercellular communication at endocrine, neuroendocrine and neuronal level. Genetic, nutritional or pharmacological interventions may help to improve ageing-related decline of cell-to-cell communication.

Aging Hallmar - Microbiome Disturbance
10

Microbiome Disturbance

Recent advancements in technologies have revealed that there are notable changes in the gut microbiome with age. An abnormal shift in the microbiome is implicated in the pathogenesis of some age-related illnesses including cardiovascular and neurodegenerative diseases.

Aging Hallmark - Compromised Autophagy
11

Compromised Autophagy

Autophagy is the process by which the cells of the body consume their components. It’s a preservation mechanism that removes dysfunctional cells and facilitates the recycling of cellular components. Autophagy plays a significant role in regulating DNA repair, and nutrient metabolism. Impaired autophagy is implicated in ageing and the causation of various diseases.

Aging Hallmark - Inflammation
12

Inflammation

Ageing is associated with high levels of inflammatory mediators such as IL-1, IL-6, C-reactive protein, IFNα, and several others in the blood. This age-related chronic inflammation is implicated in the pathogenesis of several diseases.

Aging Hallmark - Splicing Dysregulation
13

Splicing Dysregulation

Splicing, the process by which pre mRNA is transformed to mature RNA, is dysregulated in ageing. Recent research has highlighted the value of splicing profiles as a predictor of biological age and life expectancy.

Aging Hallmark - Altered Mechanical Properties
14

Altered Mechanical Properties

The mechanical properties of cells as well as the extracellular components are altered in ageing. Such changes can modify cellular behaviour and predispose to many age-related chronic diseases.

01

Genomic Instability

Various endogenous or exogenous agents cause a variety of genetic lesions. Our body has multiple mechanisms to repair these. However, excess DNA damage or insufficient DNA repair favours the ageing process.

02

Telomere Attrition

Ageing is usually accompanied by telomere attrition. Pathological dysfunction of DNA accelerates ageing. Experimental stimulation of telomerase was shown to delay ageing.

03

Epigenetic Regulation

Ageing is associated with epigenetic changes such as alterations in DNA methylation patterns, post-translational modification of histones and chromatin remodelling. Loss of function of epigenetically relevant enzymes reduces longevity whereas the gain of their function extends longevity.

04

Loss of Proteostasis

Ageing is associated with impaired protein homeostasis. Endogenous or exogenous stress leads to unfolding or misfolding of proteins. These are either repaired or destroyed through various pathways. A failure of these mechanisms lead to accumulation or aggregation of damaged proteins. Aggregation of damaged proteins lead to various age-related pathologies.

05

Deregulated nutrient sensing

The four pathways that mainly control metabolism are Insulin/IGF-1 pathway, mTOR pathway, AMPK and Sirtuins. Genetic mutations that alter the functioning of these pathways is linked to longevity. Anabolic signalling hastens ageing whereas reduced nutritional signalling facilitates longevity.

06

Mitochondrial dysfunction

Mitochondrial functioning has significant implications on the ageing process. Mitochondrial dysfunction brought on by various mechanisms, accelerates ageing through different means.

07

Cellular Senescence

Cellular senescence is a stable arrest of cell cycle in normal cells triggered by various intrinsic and extrinsic stimuli. As the organisms age, senescent cells accumulate due to widespread damage and insufficient clearing. This has deleterious impact on tissue homeostasis and contributes to ageing.

08

Stem Cell Exhaustion

Decline of stem cells occur as a consequence of various types of ageing-related cellular damages. Recent research shows that stem cell rejuvenation may be a promising approach to reverse ageing.

09

Altered Intercellular Communication

Ageing is accompanied by changes in intercellular communication at endocrine, neuroendocrine and neuronal level. Genetic, nutritional or pharmacological interventions may help to improve ageing-related decline of cell-to-cell communication.

10

Microbiome Disturbance

Recent advancements in technologies have revealed that there are notable changes in the gut microbiome with age. An abnormal shift in the microbiome is implicated in the pathogenesis of some age-related illnesses including cardiovascular and neurodegenerative diseases.

11

Compromised Autophagy

Autophagy is the process by which the cells of the body consume their components. It’s a preservation mechanism that removes dysfunctional cells and facilitates the recycling of cellular components. Autophagy plays a significant role in regulating DNA repair, and nutrient metabolism. Impaired autophagy is implicated in ageing and the causation of various diseases.

12

Inflammation

Ageing is associated with high levels of inflammatory mediators such as IL-1, IL-6, C-reactive protein, IFNα, and several others in the blood. This age-related chronic inflammation is implicated in the pathogenesis of several diseases.

13

Splicing Dysregulation

Splicing, the process by which pre mRNA is transformed to mature RNA, is dysregulated in ageing. Recent research has highlighted the value of splicing profiles as a predictor of biological age and life expectancy.

14

Altered Mechanical Properties

The mechanical properties of cells as well as the extracellular components are altered in ageing. Such changes can modify cellular behaviour and predispose to many age-related chronic diseases.

Aging Hallmark - Genomic InstabilityTelomere Attrition Cause of AgingAging Hallmar - Epigenetic RegulationAging Hallmark - Loss of ProteostasisAging Hallmark - Deregulated Nutrient SensingAging Hallmark - Mitochuondrial DysfunctionAging Hallmark - Cellular SenescenceAging Hallmark - Stem Cell ExhaustionAging Hallmark - Altered Intercellular CommunicationAging Hallmar - Microbiome DisturbanceAging Hallmark - Compromised AutophagyAging Hallmark - InflammationAging Hallmark - Splicing DysregulationAging Hallmark - Altered Mechanical Properties

51%

of the population dies due to age-related diseases

LONGEVITY SCIENCE

Predictive

Predict the genetic and lifestyle factors that influence ageing and modify them.

Predict the genetic and lifestyle factors that influence ageing and modify them.