We are going to live beyond 100

The science of longevity is constantly evolving every single day, every single second.

The average life expectancy of Indians has increased exponentially over the past two centuries, while the fertility rate is declining at an alarming rate. This change in demography is leading us to the inevitable Silver Tsunami.

Silver tsunami, founder, founders life, startup, startuplife, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing

Silver Tsunami

“When we look at this trend from a demographic perspective, we can conclude that the rate at which people are entering the retirement stage will exponentially outpace the rate at which individuals enter the workforce. The seesaw is evidently leaning towards the onset of the Silver Tsunami, in fact, it has already been done in countries like Japan.” Darshit Patel

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14 Hallmarks of Ageing

Scientifically proven root causes of why your body age.

hall marks of ageing, longevity
01

Genomic Instability

Various endogenous or exogenous agents cause a variety of genetic lesions. Our body has multiple mechanisms to repair these. However, excess DNA damage or insufficient DNA repair favours the ageing process.

hall marks of ageing, longevity,  telomere
02

Telomere Attrition

Ageing is usually accompanied by telomere attrition. Pathological dysfunction of DNA accelerates ageing. Experimental stimulation of telomerase was shown to delay ageing.

hall marks of ageing, longevity, genomic instabilility
03

Epigenetic Regulation

Ageing is associated with epigenetic changes such as alterations in DNA methylation patterns, post-translational modification of histones and chromatin remodelling. Loss of function of epigenetically relevant enzymes reduces longevity whereas the gain of their function extends longevity.

Ageing is associated with impaired protein hemostasis. Endogenous or exogenous stress leads to unfolding or misfolding of proteins. These are either repaired or destroyed through various pathways. A failure of these mechanisms lead to accumulation
04

Loss of Proteostasis

Ageing is associated with impaired protein homeostasis. Endogenous or exogenous stress leads to unfolding or misfolding of proteins. These are either repaired or destroyed through various pathways. A failure of these mechanisms lead to accumulation or aggregation of damaged proteins. Aggregation of damaged proteins lead to various age-related pathologies.

The four pathways that mainly control metabolism are Insulin/IGF-1 pathway, mTOR pathway, AMPK and Sirtuins. Genetic mutations that alter the functioning of these pathways is linked to longevity. Anabolic signalling hastens ageing whereas reduced nutritio
05

Deregulated nutrient sensing

The four pathways that mainly control metabolism are Insulin/IGF-1 pathway, mTOR pathway, AMPK and Sirtuins. Genetic mutations that alter the functioning of these pathways is linked to longevity. Anabolic signalling hastens ageing whereas reduced nutritional signalling facilitates longevity.

Mitochondrial functioning has significant implications on the ageing process. Mitochondrial dysfunction brought on by various mechanisms, accelerates ageing through different means.
06

Mitochondrial dysfunction

Mitochondrial functioning has significant implications on the ageing process. Mitochondrial dysfunction brought on by various mechanisms, accelerates ageing through different means.

Cellular senescence is a stable arrest of cell cycle in normal cells triggered by various intrinsic and extrinsic stimuli. As the organisms age, scescent cells accumulate due to widespread damage and insufficient clearing. This has deleterious impact on t
07

Cellular Senescence

Cellular senescence is a stable arrest of cell cycle in normal cells triggered by various intrinsic and extrinsic stimuli. As the organisms age, senescent cells accumulate due to widespread damage and insufficient clearing. This has deleterious impact on tissue homeostasis and contributes to ageing.

Decline of stem cells occur as a consequence of various types of ageing-related cellular damages. Recent research shows that stem cell rejuvenation may be a promising approach to reverse ageing.
08

Stem Cell Exhaustion

Decline of stem cells occur as a consequence of various types of ageing-related cellular damages. Recent research shows that stem cell rejuvenation may be a promising approach to reverse ageing.

Altered Intercellular Communication, founder, founders life, startup, startuplife, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing
09

Altered Intercellular Communication

Ageing is accompanied by changes in intercellular communication at endocrine, neuroendocrine and neuronal level. Genetic, nutritional or pharmacological interventions may help to improve ageing-related decline of cell-to-cell communication.

Microbiome Disturbance, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing
10

Microbiome Disturbance

Recent advancements in technologies have revealed that there are notable changes in the gut microbiome with age. An abnormal shift in the microbiome is implicated in the pathogenesis of some age-related illnesses including cardiovascular and neurodegenerative diseases.

Compromised Autophagy, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing
11

Compromised Autophagy

Autophagy is the process by which the cells of the body consume their components. It’s a preservation mechanism that removes dysfunctional cells and facilitates the recycling of cellular components. Autophagy plays a significant role in regulating DNA repair, and nutrient metabolism. Impaired autophagy is implicated in ageing and the causation of various diseases.

Inflammation, founder, founders life, startup, startuplife, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing
12

Inflammation

Ageing is associated with high levels of inflammatory mediators such as IL-1, IL-6, C-reactive protein, IFNα, and several others in the blood. This age-related chronic inflammation is implicated in the pathogenesis of several diseases.

Splicing Dysregulation, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing
13

Splicing Dysregulation

Splicing, the process by which pre mRNA is transformed to mature RNA, is dysregulated in ageing. Recent research has highlighted the value of splicing profiles as a predictor of biological age and life expectancy.

Altered Mechanical Properties, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing
14

Altered Mechanical Properties

The mechanical properties of cells as well as the extracellular components are altered in ageing. Such changes can modify cellular behaviour and predispose to many age-related chronic diseases.

01

Genomic Instability

Various endogenous or exogenous agents cause a variety of genetic lesions. Our body has multiple mechanisms to repair these. However, excess DNA damage or insufficient DNA repair favours the ageing process.

02

Telomere Attrition

Ageing is usually accompanied by telomere attrition. Pathological dysfunction of DNA accelerates ageing. Experimental stimulation of telomerase was shown to delay ageing.

03

Epigenetic Regulation

Ageing is associated with epigenetic changes such as alterations in DNA methylation patterns, post-translational modification of histones and chromatin remodelling. Loss of function of epigenetically relevant enzymes reduces longevity whereas the gain of their function extends longevity.

04

Loss of Proteostasis

Ageing is associated with impaired protein homeostasis. Endogenous or exogenous stress leads to unfolding or misfolding of proteins. These are either repaired or destroyed through various pathways. A failure of these mechanisms lead to accumulation or aggregation of damaged proteins. Aggregation of damaged proteins lead to various age-related pathologies.

05

Deregulated nutrient sensing

The four pathways that mainly control metabolism are Insulin/IGF-1 pathway, mTOR pathway, AMPK and Sirtuins. Genetic mutations that alter the functioning of these pathways is linked to longevity. Anabolic signalling hastens ageing whereas reduced nutritional signalling facilitates longevity.

06

Mitochondrial dysfunction

Mitochondrial functioning has significant implications on the ageing process. Mitochondrial dysfunction brought on by various mechanisms, accelerates ageing through different means.

07

Cellular Senescence

Cellular senescence is a stable arrest of cell cycle in normal cells triggered by various intrinsic and extrinsic stimuli. As the organisms age, senescent cells accumulate due to widespread damage and insufficient clearing. This has deleterious impact on tissue homeostasis and contributes to ageing.

08

Stem Cell Exhaustion

Decline of stem cells occur as a consequence of various types of ageing-related cellular damages. Recent research shows that stem cell rejuvenation may be a promising approach to reverse ageing.

09

Altered Intercellular Communication

Ageing is accompanied by changes in intercellular communication at endocrine, neuroendocrine and neuronal level. Genetic, nutritional or pharmacological interventions may help to improve ageing-related decline of cell-to-cell communication.

10

Microbiome Disturbance

Recent advancements in technologies have revealed that there are notable changes in the gut microbiome with age. An abnormal shift in the microbiome is implicated in the pathogenesis of some age-related illnesses including cardiovascular and neurodegenerative diseases.

11

Compromised Autophagy

Autophagy is the process by which the cells of the body consume their components. It’s a preservation mechanism that removes dysfunctional cells and facilitates the recycling of cellular components. Autophagy plays a significant role in regulating DNA repair, and nutrient metabolism. Impaired autophagy is implicated in ageing and the causation of various diseases.

12

Inflammation

Ageing is associated with high levels of inflammatory mediators such as IL-1, IL-6, C-reactive protein, IFNα, and several others in the blood. This age-related chronic inflammation is implicated in the pathogenesis of several diseases.

13

Splicing Dysregulation

Splicing, the process by which pre mRNA is transformed to mature RNA, is dysregulated in ageing. Recent research has highlighted the value of splicing profiles as a predictor of biological age and life expectancy.

14

Altered Mechanical Properties

The mechanical properties of cells as well as the extracellular components are altered in ageing. Such changes can modify cellular behaviour and predispose to many age-related chronic diseases.

hall marks of ageing, longevityhall marks of ageing, longevity,  telomerehall marks of ageing, longevity, genomic instabililityAgeing is associated with impaired protein hemostasis. Endogenous or exogenous stress leads to unfolding or misfolding of proteins. These are either repaired or destroyed through various pathways. A failure of these mechanisms lead to accumulation The four pathways that mainly control metabolism are Insulin/IGF-1 pathway, mTOR pathway, AMPK and Sirtuins. Genetic mutations that alter the functioning of these pathways is linked to longevity. Anabolic signalling hastens ageing whereas reduced nutritioMitochondrial functioning has significant implications on the ageing process. Mitochondrial dysfunction brought on by various mechanisms, accelerates ageing through different means. Cellular senescence is a stable arrest of cell cycle in normal cells triggered by various intrinsic and extrinsic stimuli. As the organisms age, scescent cells accumulate due to widespread damage and insufficient clearing. This has deleterious impact on tDecline of stem cells occur as a consequence of various types of ageing-related cellular damages. Recent research shows that stem cell rejuvenation may be a promising approach to reverse ageing. Altered Intercellular Communication, founder, founders life, startup, startuplife, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageingMicrobiome Disturbance, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageingCompromised Autophagy, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageingInflammation, founder, founders life, startup, startuplife, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageingSplicing Dysregulation, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageingAltered Mechanical Properties, longevity, reverse ageing, anti ageing, health span, community, reverse ageing, slow ageing

51%

of the population dies due to age-related diseases

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Predict the genetic and lifestyle factors that influence ageing and modify them.

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