Loss of male sex chromosome leads to shortened longevity for men

decodeage decode age senolytic healthy ageing longevity reverse ageing nmn nad+ booster gut microbiome biological age test senolytic ageing chronic disease

      The X and Y chromosome

      A pair of sex chromosomes is one of the 23 pairs of chromosomes found in human cells.

      Every bodily cell has the X chromosome. It contains our genes, or the codes for our inherited characteristics.

      Persons who are naturally male have one X and one Y chromosome, whereas biologically feminine people have two X chromosomes (XX) (XY).

      The X chromosome is now about three times the size of the Y chromosome and contains about 900 genes, whereas the smaller Y chromosome has only about 71 genes and has lost about 97% of its ancestral genes, despite deriving from the same pair of autosomes (non-sex chromosomes).

      The Y chromosome had previously been thought to have a very little impact. It has also been suggested that the Y chromosome contains very little genetic information.

      Men don't simply lose their hair, muscular mass, and cartilage in their knees as they age. Additionally, they begin losing Y chromosomes from their cells. Genetic decay has also wreaked havoc on the Y chromosome.

      What happens when men lose their Y chromosome?

      The Y chromosome, while having a reputation for being strong, is a wimp, carrying just 71 genes, or less than one-tenth as many as the X chromosome.

      That might be the reason the chromosome isn't always passed on when a cell divides.

      The simplest method to identify Y loss is to analyse blood samples, and researchers have discovered that the chromosome is absent from certain white blood cells in roughly 40% of 70-year-olds and 57% of 93-year-olds.

      More than 80% of the cells in certain elderly males may lack a Y chromosome.

      Even though cells without a Y chromosome can still live and grow, males who lack this chromosome in part of their cells are more prone to develop heart disease, cancer, Alzheimer's disease, and other age-related diseases.

      Additionally, the illness may be the cause of males dying on average 5 years earlier than women.

      Smokers tend to be more susceptible to the loss of the Y chromosome, which mostly affects cells that divide quickly, such as blood cells.

      Men who lose their Y chromosome are more likely to die early and develop age-related diseases like Alzheimer's disease, according to research.

      So is it true that Men are dying?

      Even if the Y chromosome does vanish in humans, this does not necessarily indicate that males as a species would follow suit. Males and females are both required for reproduction, even in organisms that have fully lost their Y chromosomes.

      These species may create men without the need for a Y chromosome because the SRY "master switch" gene, which controls genetic maleness, has shifted to a separate chromosome in these instances.

      The same lack of recombination that killed their previous Y chromosome should then cause the new sex-determining chromosome, the one that SRY goes on to, to begin the degeneration process all over again.

      In conclusion,

      Humans are unique in that, despite the Y chromosome's requirement for normal human reproduction, many of the genes it contains are not required if you employ assisted reproductive technologies.

      As a result, same-sex female couples or infertile males may soon be able to conceive thanks to genetic engineering, which might replace the Y chromosome's gene function.

      Even if everyone could conceive in this manner, it seems exceedingly improbable that fertile people would suddenly quit procreating normally.

      Reading next

      Three risk factors in your 50s that could greatly influence longevity – assess risk
      decodeage decode age senolytic healthy ageing longevity reverse ageing nmn nad+ booster gut microbiome biological age test senolytic ageing chronic disease, exercise diet longevity

      Leave a comment

      This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.