Exploring Fisetin: Understanding Its Mechanism and Health Benefits

Exploring Fisetin: Understanding Its Mechanism and Health Benefits

      Fisetin, a bioactive flavonol compound, is primarily present in fruits and vegetables like strawberries, apples, persimmons, onions, and cucumbers. It falls under the flavonoid category of polyphenols, renowned for their strong antioxidant characteristics. Fisetin has garnered attention in scientific research due to its diverse range of biological functions, encompassing anti-inflammatory, antioxidant, neuroprotective, and potent senolytic effects.

      What are the Benefits of Decode Age Fisetin?

      Fisetin is recognised as a potent senolytic activator due to its ability to selectively induce apoptosis in senescent cells, which are cells that have stopped dividing and play a role in ageing and age-related illnesses. Fisetin's efficacy as a senolytic agent is attributed to various mechanisms, such as: 

      Eliminates Senescent cells

      Emerging research suggests that fisetin may also have senolytic capabilities, meaning it can selectively induce death in senescent cells—cells that have ceased to divide and contribute to ageing and age-related diseases. Fisetin is thought to target these cells by disrupting their survival pathways, thereby reducing the overall burden of senescent cells and potentially ameliorating age-related tissue dysfunction.

      Disruption of Survival Pathways

      Senescent cells often evade apoptosis through specific survival pathways. Fisetin disrupts these pathways, mainly by reducing the levels of anti-apoptotic proteins and pro-survival networks within senescent cells, ultimately causing their apoptosis.

      Antioxidant Properties

      Fisetin operates mechanistically by engaging in multiple cellular pathways. Acting as an antioxidant, it seeks out free radicals, thereby diminishing oxidative stress and preventing potential cellular damage. Its anti-inflammatory properties stem from its ability to inhibit particular enzymes (e.g., lipoxygenases) and signalling molecules (such as NF-κB) responsible for triggering inflammatory responses, consequently alleviating cellular inflammation.


      The neuroprotective effects of Fisetin stem from its ability to improve neuronal function and shield against neurotoxicity. It sustains cognitive capabilities by preserving synaptic plasticity and shielding neurons from age-related deterioration. This is partly achieved through the activation of signalling pathways that foster neuronal survival and its antioxidative properties, which guard against oxidative harm in neural tissues.

      These mechanisms, combined with Fisetin's established safety profile, highlight its promise as a potent senolytic activator. Ongoing research and clinical investigations aim to delve deeper into Fisetin's modes of action and its potential therapeutic applications in age-related conditions and diseases associated with cellular senescence.

      Recommended Dosage and Timing

      Our supplement is designed to help support your overall health and well-being. Here are some guidelines for taking our supplement:

      When to Take It

      We recommend taking one capsule daily after dinner or as directed by your healthcare professional. This will help ensure that the supplement is properly absorbed and utilized by your body.

      Does Decode Age Fisetin contain Strawberry Extract?

      Decode Age's Fisetin is sourced from strawberry extract, being its richest source.  Due to the premium encapsulation, the bioavailability of Fisetin is enhanced.

      Can I Take Fisetin?

      • Health Conditions: If you have underlying health conditions or are on medication, it's essential to consult with a healthcare provider before starting Fisetin.
      • Pregnancy and Breastfeeding: There is limited research on Fisetin's effects during pregnancy and breastfeeding. It's advisable to avoid Fisetin supplementation during these periods.
      • Age Factor: Fisetin is primarily researched for its benefits in ageing. Young individuals, especially those under 18, should consult a healthcare provider before use.
      Fisetin Decode Age


      In conclusion, Fisetin, a potent bioactive flavonol found in fruits like strawberries, shows promising senolytic traits by targeting and removing senescent cells associated with ageing and age-related diseases. Its varied mechanisms, including apoptosis induction and antioxidant properties, highlight its therapeutic potential. Optimal supplementation and lifestyle adjustments are crucial for maximising its benefits while ensuring safety. Ongoing research aims to discover further therapeutic applications for age-related conditions.


      Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep 
      (Huard, C. A., Gao, X., Dey Hazra, M. E., Hazra, O. D., Lebsock, K., Easley, J. T., Millett, P. J., & Huard, J. (2023). Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep. Antioxidants, 12(8).)


      1) Which food has the highest amount of Fisetin?

      The food with the greatest abundance of Fisetin is strawberries. Among all food options, strawberries stand out as an excellent source of Fisetin, boasting approximately 160 grams of this beneficial compound per serving.

      2) Is Fisetin good for the liver?

      Yes, Fisetin is beneficial for the liver as it promotes the upregulation of hepatic enzymes responsible for fatty acid oxidation and lipid exportation. This process is facilitated through the activation of the adiponectin-AMPK pathway, ultimately contributing to the improvement of conditions such as alcoholic fatty liver.

      3) Can I take Decode Age Quercetin and Fisetin together?

      Yes, taking Decode Age’s Quercetin and Fisetin together may yield beneficial results. Both quercetin and fisetin exhibit comparable tumour inhibition properties, potentially leading to a synergistic effect when used in conjunction. Their simultaneous administration could impact distinct pathways or the same specific pathway, potentially eliminating senescence cells.

      4) Does fisetin remove senescent cells?

      Yes, fisetin has been identified as a potent senolytic activator. It selectively induces apoptosis, or programmed cell death, in senescent cells. These cells, which have ceased dividing, contribute to ageing and age-related diseases. Fisetin's ability to target and remove senescent cells makes it a promising candidate for combating age-related illnesses.

      Reading next

      What is Ca-AKG (Calcium Alpha-Ketoglutarate) and how does it work?

      Leave a comment

      This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.