Best Fisetin Supplements in 2025

Fisetin might not be as mainstream as resveratrol or NMN yet, but that’s changing fast. This powerful flavonoid, found naturally in fruits like strawberries and apples, is earning serious attention in the world of longevity and brain health. And in 2025, the market is brimming with advanced fisetin supplements designed to enhance its absorption and effects. 

Read more: Fisetin: A Powerful Senolytic that Slows Down the Ageing Process 

“Fisetin has shown more senotherapeutic activity than any other flavonoid we've tested.” 
 — Dr. James Kirkland, Director of the Robert and Arlene Kogod Center on Aging, Mayo Clinic 

Let’s unpack what fisetin really does, how to choose the best fisetin supplement, and what dosage is ideal for benefits like cellular repair, brain clarity, and anti-inflammatory support. 

Raed more: Discover Decode Age Fisetin: Benefits, Dosage & Timing. 

What is Fisetin? 

Fisetin is a plant-based flavonoid that plays antioxidant, anti-inflammatory, and senolytic roles in the body. Researchers first became interested in it for its neuroprotective effects, but it’s now gaining fame as a senolytic, meaning it helps clear senescent cells, which are dysfunctional, ageing cells that accumulate and drive chronic inflammation and tissue damage. 

It is commonly found in strawberries, apples, persimmons, and onions, but in small quantities. That’s why fisetin supplements are designed to deliver concentrated doses, often 100mg, 500mg, or even 1000mg per capsule, for clinical health benefits. 

Fisetin Uses and Health Benefits 

The most researched fisetin supplement benefits include: 

• Senolytic activity: Helps flush out senescent “zombie” cells, supporting cellular regeneration and healthy ageing. 
• Brain health: Crosses the blood-brain barrier, reducing neuroinflammation and improving memory in animal studies. 
• Antioxidant defense: Neutralises reactive oxygen species (ROS) and reduces oxidative stress at the cellular level. 
• Anti-inflammatory action: Reduces chronic inflammation, linked to diseases like arthritis, diabetes, and Alzheimer’s. 

Recent animal studies (mouse models) even suggest fisetin may extend lifespan and healthspan when used routinely. 

Fisetin in Food: Is It Enough? 

You’ll find fisetin in food, but not nearly at therapeutic levels. Here are the top fisetin-rich foods: 

So, to match a 500mg fisetin supplement dose, you’d need to eat over 300g of strawberries daily. Not impossible, but not ideal for consistency either. 

How to Take Fisetin for Best Results 

The best way to take fisetin is in supplement form, with food (preferably fats) to enhance absorption. It is fat-soluble, and bioavailability can be quite low without enhancement. 

Many high-quality fisetin capsules are now formulated with: 

• Liposomal delivery 
• Micronized particles 
• Combination with quercetin (for synergistic senolytic effects) 

Stacking fisetin with quercetin can enhance its effects, particularly in clearing senescent cells. This combo gained popularity in 2025 as a more complete senotherapeutic stack. 

Optimal Fisetin Supplement Dosage 

There’s no universally established dosage, but these ranges are based on clinical and preclinical research: 

• Everyday support: 100–200mg/day or max 500mg/day 
• Senolytic protocol (cycling): 1000mg for 2 consecutive days/month 

Clinical trials such as the AFFIRM-LITE study (phase 2 trial) explore fisetin’s effects in humans, especially in ageing and inflammation-related conditions. 

Caution: High doses should be taken cyclically, not continuously, unless under supervision. Always consult a health expert. 

Best Fisetin Supplements in 2025: Ranked 

After comparing dozens of formulas, ingredient profiles, and user reviews, these are the top fisetin supplements worth considering in 2025: 

Decode Age Fisetin 

Available Dose: 100 mg | Form: Vegetarian capsule 

Decode Age’s fisetin supplement delivers100 mg of fisetin per capsule. It is sourced from strawberry extract and is known for its high purity (99%) and advanced encapsulation technology that boosts bioavailability up to 50 times. It is manufactured in ISO- and GMP-certified facilities under pharmaceutical-grade standards, and each batch undergoes third-party testing for purity and heavy metals. The formulation is clean, gluten-free, soy-free, and free from fillers.  

Decode Age SeneVit 

Available Dose: Fisetin 75 mg | Form: Vegetarian capsule 

SeneVit is a multi-ingredient senolytic formulation to offer holistic cellular rejuvenation. Each vegetarian capsule contains 75 mg of fisetin (from strawberry extract), 140 mg of quercetin (from Sophora japonica), 100 mg of apigenin (from chamomile), and 30 mg of piper longum (black pepper extract). The formula is known for synergistic action- quercetin and apigenin enhances antioxidant and anti-inflammatory effects, while piperine increases the bioavailability of the flavonoids. 

It is manufactured in GMP-certified facilities and tested for contaminants and heavy metals. SeneVit offers a well-rounded alternative for those looking to support longevity, cellular detox, and neuroprotection through natural plant compounds. 

Life Extension Bio-Fisetin 

Available Dose: 200 mg | Form: Vegetarian capsule 

Life Extension’s Bio-Fisetin is bound to fenugreek galactomannan, which enhances the absorption up to 25 times compared to standard fisetin. It is manufactured in GMP-compliant facilities with reliable quality control. This product supports users looking for moderate, daily antioxidant benefits. 

Renue by Science Lipo Fisetin 

Available Dose: 150 mg | Form: Vegetarian Capsule 

Renue by Science’s LIPO Fisetin offers a 150 mg dose of fisetin in a liposomal capsule to overcome poor oral bioavailability. It ensures enhanced absorption and sustained release, meaning fisetin stays in the bloodstream longer and is more effectively used by the body. The formulation is free from major allergens and crafted in GMP-certified facilities for optimal purity and stability. 

Doctor’s Best Fisetin 

Available Dose: 100 mg | Form: Vegetarian capsule 

Doctor’s Best Fisetin features 100 mg of fisetin extracted from Rhus succedanea (wax tree). It offers a clean, no-filler formulation intended for basic antioxidant and cognitive support. Manufactured in a cGMP-compliant facility in the USA, the product is non-GMO, gluten-free, and soy-free. While it lacks advanced bioavailability enhancers like piperine or liposomes, it serves as an affordable entry into senolytic supplementation. 

Fisetin and Quercetin: Should We Take Them Together? 

Fisetin and quercetin are both flavonoids with senolytic activity. Studies show that when taken together, they may act on different types of senescent cells, making the stack more effective. 

This duo is now featured in many advanced supplements in 2025 and for good reason. Together, they enhance mitochondrial health, reduce inflammatory cytokines, and support metabolic function. 

FAQs 

What is fisetin and what does it do in the body? 

Fisetin is a natural flavonoid found in strawberries, apples, and onions. It works as a senolytic, meaning it helps clear out senescent or “zombie” cells that contribute to ageing. Fisetin also acts as an antioxidant and anti-inflammatory agent, supporting brain health, skin clarity, and metabolic balance. Studies suggest it may even extend lifespan in animals and promote healthier ageing in humans. 

Can I get enough fisetin from food alone? 

Not really. While strawberries are a good source (around 160 mg per 100 g), you’d need to eat 300–500 grams daily to match supplement doses like 500 mg. Fisetin in food supports basic health, but for deeper cellular or senolytic benefits, supplementation is usually needed. That’s where high-quality fisetin capsules like those from Decode Age or Renue by Science can help bridge the gap. 

Is it safe to take fisetin every day? 

Low doses of fisetin (around 100–200 mg per day) are generally safe and well tolerated. However, higher doses used for senolytic effects (e.g., 1000 mg) should be taken in cycles, not daily. Always talk to a healthcare provider before starting any new supplement, especially if you're combining fisetin with other antioxidants like quercetin. 

What is the difference between fisetin and quercetin? 

Both are flavonoids with antioxidant and anti-inflammatory properties, but fisetin is a stronger senolytic. Quercetin is better known for immune support and allergy control, while fisetin targets ageing cells more directly. Some supplements, like Decode Age’s SeneVit, combine both for enhanced results—clearing senescent cells and supporting overall longevity.