What is NMN and How Does It Slow Ageing?

NMN (Nicotinamide Mononucleotide) is a molecule that helps boost NAD+ levels in the body, a coenzyme essential for over 500 cellular functions. As we age, NAD+ levels naturally decline, leading to reduced energy production, increased inflammation, and cellular damage. NMN supplementation can restore NAD+ levels, improving mitochondrial function, insulin sensitivity, muscle performance, and brain health.

Key Benefits of NMN:

• Metabolic: Better insulin sensitivity and glucose uptake.
• Cardiovascular: Improved heart function and reduced inflammation.
• Muscular: Enhanced muscle responsiveness and performance.
• Cellular: Improved DNA repair and mitochondrial health.
• Neurological: Reduced fatigue and better neuronal activity.

Dosage Recommendations:

• 250 mg/day: Beginners or younger adults.
• 500–1000 mg/day: Middle-aged adults or regular users.
• 1000–1200 mg/day: Athletes or older adults.

Safety:

NMN is generally safe up to 1200 mg/day, with mild side effects like stomach upset or headaches in some cases. For best results, take NMN in the morning on an empty stomach.

NMN shows promise in slowing age-related decline, but more research is needed to confirm long-term effects. Always consult a healthcare professional before starting supplementation.

How NMN Works in the Body

NMN to NAD+ Conversion

NMN is converted into NAD+ through the action of NMN adenylyltransferases (NMNATs) [1]. The transporter Slc12a8 helps NMN enter cells, while extracellular vesicles assist in distributing it throughout the bloodstream [2]. This process is important because NAD+ levels naturally decline as we age. Since NAD+ plays a key role in maintaining cellular function, its reduction over time is closely tied to the ageing process.

Age-Related NAD+ Decline

As we get older, NAD+ levels drop across various tissues, including the brain and other vital organs. Dr. Shin-ichiro Imai from Washington University described this process in striking terms:

"The slow, ineluctable process of ageing has been described as a 'cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues." [2]

Several factors contribute to this decline in NAD+:

Supplementing with NMN can help counteract these effects by replenishing NAD+ levels. Studies suggest that NMN supplementation can restore NAD+ levels, leading to improvements in mitochondrial function, insulin secretion, and neuronal health [2]. By addressing the drop in NAD+, NMN tackles the cellular changes linked to ageing.

NMN's Effects on Ageing

Main Health Benefits

NMN supplements help restore NAD⁺ levels, which play a crucial role in improving metabolic, cardiovascular, muscular, cellular, and neurological functions. Studies suggest these improvements may address various age-related health issues.

"Recent breakthroughs reveal that NAD⁺ cannot be delivered directly; instead, supplying NMN - the NAD⁺ precursor - is key, as cells actively transport NMN and convert it into NAD⁺." - Professor Andrew Salzman, MD, Harvard Medical School alumnus and drug inventor

Research Results

Both clinical and animal studies back up these benefits:

• A 2021 study involving overweight, postmenopausal women with prediabetes found that taking 250 mg of NMN daily for 10 weeks improved muscle insulin sensitivity and skeletal muscle signaling [3].
• In 2023, a study on 48 amateur runners (ages 27–50) revealed that daily NMN doses ranging from 300 to 1200 mg over six weeks boosted aerobic capacity in a dose-dependent manner compared to a placebo group.
• Another 2023 study showed that while 250 mg of NMN daily for 12 weeks didn’t improve sleep quality in older adults, taking it in the afternoon enhanced muscle responsiveness and reduced fatigue.

Animal studies also highlight NMN’s potential in hemorrhagic shock scenarios by:

• Lowering lactic acidosis levels
• Reducing serum IL-6 inflammation markers
• Extending shock tolerance by nearly 25%
• Improving survival rates after resuscitation (P = 0.018)

"Finding an effect in muscle tissue is very interesting and does demonstrate that NMN is not inert. But it's premature to make any clinical recommendations based on the results from our study. NMN needs to be tested in more people and for longer periods of time to determine if it has anti-ageing effects in humans." [3]

These findings suggest NMN could play an important role in addressing age-related decline, though more extensive research is needed.

Using NMN Supplements

Dosage Guidelines

Getting the right daily dose of NMN is key to effective supplementation. Research suggests different doses depending on your goals and individual needs.

For best results, take NMN in the morning on an empty stomach. This helps with absorption and provides steady energy throughout the day.

Safety Information

Clinical studies show that NMN is generally safe, even at doses up to 1,200 mg per day, with minimal side effects reported. However, some users might experience mild symptoms:

"The real breakthrough that occurred recently is our understanding of how to get NAD levels closer to those of our youth. We now know that it can't be done by delivering NAD either orally or by IV - because NAD has no mechanism for entering the cell. However, it can be done by providing the starting material for NAD, which is NMN. Cells have evolved a receptor for NMN - it's a special protein on the surface of the cell which attaches to NMN and shuttles it into the cell. Once inside, NMN is converted by cellular enzymes to create NAD." - Professor Andrew Salzman, MD

NMN and Other Supplements

To get the most out of NMN, consider these tips:

• Start Small: Begin with 250 mg daily to see how your body reacts.
• Track Progress: Pay attention to energy levels, sleep patterns, and any side effects during the first few weeks.
• Increase Gradually: If necessary, slowly raise your dosage while observing how your body responds.

Here are some additional safety reminders:

• Look for products with third-party testing certifications to ensure quality.
• Consult a healthcare professional before starting NMN, especially if you're on other medications.
• Morning doses are ideal for better absorption and results.
• Keep an eye out for any unusual reactions, especially when starting out.

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Conclusion: NMN for Better Ageing

Key Takeaways

NMN helps boost cellular energy by replenishing NAD+ levels, a coenzyme critical for over 500 cellular functions. Research highlights its potential in enhancing insulin sensitivity and signaling in muscle tissue, particularly for postmenopausal women.

How to Get Started

If you're considering adding NMN to your routine, here are some general dosage guidelines based on age and activity level:

To maximize the benefits:

• Take NMN supplements first thing in the morning on an empty stomach.
• Protect your skin from UV exposure.
• Incorporate short HIIT sessions into your fitness routine.
• Track your energy levels and performance regularly.
• Consider testing biological markers to understand your progress.

Keep in mind, NAD+ levels typically drop back to baseline if NMN supplementation is discontinued. Consult with a healthcare professional to determine the right dosage for your individual needs and goals.

How Decode Age Helps with NMN Supplementation

Decode Age offers NMN supplements in various forms and dosages, designed to support NAD+ levels and promote anti-ageing benefits. Decode Age NMN comes in β- form.

The β-form of NMN is more bioavailable and effective form of NMN. It has been shown to be more efficiently taken up by cells, helping to increase NAD+ levels more effectively. This form of NMN is crucial for those looking to experience optimal anti-ageing benefits since it facilitates a smoother conversion to NAD+ within the body.

Conclusion

NMN (Nicotinamide Mononucleotide) supplementation has shown significant potential in supporting healthy ageing by replenishing NAD+ levels in the body. As we age, NAD+ naturally declines, leading to various cellular issues such as reduced energy, muscle weakness, and cognitive decline. By supplementing with NMN, we can counteract this decline and support essential cellular functions that are crucial for maintaining overall health.

Through regular NMN use, benefits such as improved metabolic health, enhanced muscle performance, better cardiovascular function, and improved brain activity can be achieved. While NMN is not a miracle cure, it does provide a valuable tool for promoting vitality and potentially slowing age-related decline.