Nobody likes gaining unhealthy weight and having a jelly belly that hangs. Thanks to the sedentary lifestyle, poor diet and increasing environmental crisis, the current population’s health is only declining. All these factors are not only causing diseases but also increasing the rate of the ageing process. It is not an uncommon sight to see a 25-year-old being obese and succumbing to cardiovascular disorders. Amidst this chaos, there’s still hope, thanks to the advancements in the healthcare sector and longevity science.
With years and years of research, scientists have now introduced many key molecules that target each process involved in ageing at a molecular level. One such groundbreaking anti-ageing supplement with the potential to revolutionise your life is NMN (nicotinamide mononucleotide). With its healthy properties, the NMN supplement can be a game-changer in maximising your health and vitality.
So, grab a healthy snack as we unravel the benefits of the emperor of anti-ageing supplements, NMN, that aids in boosting metabolism and also in weight reduction.
Understanding what is metabolism
We must have heard “your metabolism is really good” in a regular conversation but what exactly is metabolism? The human body carries out several biochemical reactions, for instance, the conversion of food into glucose which ultimately gives energy or the breakdown of fats. Many such chemical reactions are collectively called “metabolism”. The ultimate goal of all the chemical processes is to provide energy.
All the normal bodily functions such as breathing, circulation, digestion, cell growth and repair, temperature regulation, everything constitute metabolism
How NMN supplements improves metabolism
NMN supplements improve metabolism by increasing NAD+ levels in the body. NAD+ plays a crucial role in converting food into energy by facilitating metabolic reactions. NAD+ levels decline with age, and this decline is thought to contribute to the ageing process.
By increasing NAD+ levels, NMN supplements may improve metabolism by:
- Boosting energy production: NAD+ is a key player in the production of ATP, which is the main source of energy for cells. By increasing NAD+ levels, NMN supplements may enhance ATP production and improve energy levels.
- Enhancing mitochondrial function: NAD+ is also involved in the regulation of mitochondrial function, which is crucial for energy production. By improving mitochondrial function, NMN supplements may increase metabolic efficiency.
- Regulating gene expression: NAD+ is involved in the regulation of gene expression, which can impact metabolism. By modulating gene expression, NMN supplements may improve metabolic function.
The AMPK pathway and the sirtuin genes are also responsible for regulating metabolism. The AMPK pathway is also called the master switch of metabolism. The AMPK pathway and Sirtuins, the longevity gene, are dependent on the NAD+ levels in the body.
how NMN supplements aids weight loss
Weight gain occurs when there’s excess fat and very little physical activity to break down those fats into energy. This is also a consequence of slowed metabolism where the fat metabolism is impaired. Anti ageing supplements NMN targets the key players in metabolism and aids in weight loss.
As mentioned previously, it aids in the activation of Sirtuins and also obesity is often associated with inflammation and reduced NAD+ levels, which can lead to poor Sirtuins functioning. Sirtuins as mentioned previously play a crucial role in regulating brain function, metabolism, inflammation, and caloric restriction, making them an important target for preventing obesity and premature death.
Caloric restriction is one of the most effective ways to activate Sirtuins, however, that is easier said than done. Sirtuins are heavily dependent on NAD+ levels. Thus by replenishing the cells with NAD+, Sirtuins levels can be increased and ultimately, this combined effect can prove beneficial in managing obesity and aid weight loss.
Increasing NAD+ levels through supplements like NMN promotes SIRT1 activation, leading to metabolic improvement, neuroprotection, cardioprotection, and antioxidant effects. A study featured in Cell Metabolism reported that mice that were administered doses of 100 or 300 mg/kg of NMN for 12 months demonstrated weight reductions of 4% and 9%, respectively. Interestingly, NMN did not bring about weight loss by curbing appetite, but rather by elevating energy expenditure and oxygen consumption.
As excessive body weight is a significant risk factor for several chronic conditions, NMN may be a valuable tool for supporting weight management and overall health.
Other health benefits of NMN supplements
1. Supports brain health
Age-related cognitive decline is common and is often caused by decreased brain NAD+ levels, which can impair mitochondrial function. However, replenishing NAD+ stores with NMN can prevent this dysfunction. Research has shown that NMN supplementation can inhibit the formation of beta-amyloid plaques associated with neurological conditions and enhance spatial working memory, coordination, and neurovascular health in older mice.
2. Aids in reproductive health management
A study published in Cell Reports revealed that reproductively aged female mice administered with low-dose NMN demonstrated significant improvements in birth rates, reduced time to pregnancy, and better outcomes in vitro fertilisation. These positive effects on reproductive health could be attributed to NMN's weight-management benefits, as excess body weight is a risk factor for infertility. The findings suggest that low-dose NMN supplementation could potentially serve as a non-invasive and low-risk approach to enhance fertility and support pregnancy in women of advanced age in the future.
3. Promotes Longevity
As we age, the vital organelles of our cells, Mitochondria, gradually lose their efficacy and decrease in number. This decline can be attributed to the reduction in NAD+ levels. Ultimately, this cellular ageing leads to a state called cellular senescence where the cells lose their ability to divide and lose their functionality. However, these senescent cells don't exit the body but instead remain in a "zombie-like" state, triggering a harmful chain reaction of inflammatory compounds that contribute significantly to the ageing process.
One promising approach to counteracting this decline is through the use of NMN, a primary precursor to NAD+. By supplementing with NMN, we may be able to mitigate cellular and mitochondrial dysfunction associated with ageing. Although it takes decades and millions of dollars to conduct human longevity studies, animal research has provided some promising results.
Studies have shown that increasing NAD+ synthesis can extend the lifespan of yeast, worms, and flies. In rodents, research has also indicated that supplementing with NMN can help prevent the decline in NAD+ levels and the physiological deterioration of organs that lead to age-related disorders.
How to consume NMN supplements
if you have decided to embark upon the longevity journey by taking NMN supplements then it is advised to adhere to these general guidelines before you consume them:
- Seek medical supervision: although safe to consume, it is always best to seek your healthcare advisor before consuming any new supplement. They can advise you on the appropriate dosage and potential interactions with any medications you may be taking.
- Recommended dosage: NMN supplements come in various dosages, ranging from 250 mg to 1000 mg. It is recommended to start with a low dose and gradually increase it over time. The recommended dosage typically ranges from 250mg to 500mg per day.
- Take NMN with food: NMN is more effective when taken with food.
- Choose high-quality supplements: Choose a reputable NMN supplement brand that uses high-quality ingredients and has undergone third-party testing to ensure purity and potency.
Weight loss isn’t a piece of cake. It requires persistence and dedication. While supplements alone cannot do wonders, NMN supplements have shown promising results in improving metabolism and aiding in weight loss. By increasing NAD+ levels in the body, NMN can boost energy production, enhance mitochondrial function, and regulate gene expression. It can also activate sirtuins, which are crucial for regulating brain function, inflammation, and caloric restriction, ultimately contributing to the management of obesity and weight loss. Additionally, NMN supplementation has also shown potential in supporting brain health, reproductive health, and promoting longevity. NMN benefits could potentially be a game-changer in maximising overall health and vitality. However, it is always recommended to consult a healthcare professional before starting any supplementation.
1. What are NMN Supplements, and how do they work to boost metabolism and promote weight loss?
NMN supplements are precursors of NAD+ molecules which are involved in energy metabolism. They work by boosting the levels of NAD+, a coenzyme involved in various metabolic processes, which can promote weight loss and reverse ageing
2. Are NMN Supplements safe to take, and what are the recommended dosages?
NMN supplements are generally safe to take at recommended dosages, but more research is needed to determine their long-term safety. Recommended dosages range from 125-500mg per day.
3. Can NMN Supplements help individuals to burn fat and lose weight, even without changes to diet or exercise habits?
While NMN supplements may promote weight loss and boost metabolism, NMN alone is not sufficient for weight loss. Changes to diet and exercise habits are still necessary.
4. How does NMN impact energy levels and overall physical performance?
NMN can impact energy levels and physical performance by increasing NAD+ levels, which can enhance mitochondrial function and cellular metabolism.
5. How can individuals incorporate NMN Supplements into a comprehensive approach to weight loss and overall health?
NMN supplements can be incorporated into a comprehensive approach to weight loss and overall health by combining them with a balanced diet, regular exercise, and other healthy habits such as getting enough sleep and managing stress. However, it's important to consult a healthcare professional before starting any supplement regimen.