NAD is one of the salient candidates in ageing research. The reason that makes NAD of great interest to scientists and entrepreneurs is its serviceable anti-aging effects. Research continues to suggest that it is going to be "there" for a while.
What is NAD ?
As a part of cellular metabolism, NAD is called nicotinamide adenine dinucleotide, an ubiquitous molecule in all life forms as complex as humans.
What is the function of NAD ?
1. This means NAD functions to convert nutrition into energy in the form of ATPs.
2. Another aspect of its function is that it controls defensive genes to prevent ageing and diseases. NAD participates in oxidation-reduction reactions along with its hydrogenated form, NADH, passing electrons from one molecule to the other.
3. It also drives sirtuins to moderate the rates of metabolism and sleep/wake cycles, both of which have direct links to the prevention of aging.
4. This molecule also helps repair DNA damage and maintain stable chromosomes, contributing to overall health and healthy aging.
How is NAD related to aging ?
As we age, NAD levels start to decrease. It is reduced in several ways, such as by PARP, sirtuins, and the immune system. As age proceeds, DNA damage accumulates; this activates the enzyme PARP, which uses NAD+ to perform DNA repair, which results in NAD depletion. This depletion further causes inflammation and age-related diseases. Sirtuins are another class of enzymes that use NAD to maintain DNA stability. With age, sirtuins consume more NAD with increased DNA instability. The enzymes of our immune system also use NAD. The more inflammation, the more active immune response and the more NAD usage, the lower the NAD levels in the body.
Reduced levels of NAD are observed to be linked with disturbed metabolic conditions like obesity and insulin resistance. These conditions may result in high blood pressure or other heart function decline, which may send decline pressure to the brain, causing cognitive impairment. NAD decline contributes to the onset of age-related diseases. Targeting NAD+ metabolism in mouse models has shown promising results in a variety of disease conditions where age-related diseases have been shown to reverse.
How does reverse targeting of NAD help in slowing down aging ?
The prevention of NAD depletion has many potential benefits. Sirtuins have helped in slowing down ageing by reducing cellular stress with the help of NAD replenishment. Its effects have been shown in many species, such as yeast, worms, and mice. These effects can be translated to humans. Restoring NAD concentration has shown improved muscle function as well as heart function. In mouse models, giving them NAD+ boosters has been shown to reduce diet-related and age-related obesity. The capacity for exercise has also been shown to increase, even in aged mice. Neurodegeneration has also been prevented due to NAD+ boosters.
NAD has been successfully shown to increase lifespan in mice. In the case of mice, it is often referred to as the "Fountain of Youth" by scientists. They are so inspired by the successful results that some have started taking NAD supplements themselves, as they like to say in interviews. Supplements are responsible for promoting healthier lifespans.
By fasting and mild exercise, we can increase the NAD production in our bodies. Such conditions increase the NAD concentration due to the moderate stress generated on the body systems. Another way we can increase the NAD levels in the body is through NAD supplements. Supplements in the form of both NAD and its precursors, such as NR, can prevent ageing and reduce the risk of age-related diseases in humans. Longevit by Life Elements contains key ingredients NMN, NAD, and CoQ10, which have been shown to have both short- and long-term benefits. To learn more about Longevit, head up here! ..