The role of NAD+ molecules is crucial for your health. In this blog we will be telling you about
some lifestyle habits that cause changes in the NAD+ levels in your body.
1. NAD+ Levels, Caloric Restriction, and Eating Habits-
When calories wererestricted by 25–60% compared to their routinely fed control, a significant increase inlifespan was observed in many experimental organisms. NAD+ levels rise, NADH levels fall, and sirtuins are activated when calories are restricted. Caloric restriction experiments demonstrated that raising the overall amount of cellular NAD+ is less essential than changing the ratio of NAD+ to NADH.
Because NADH is an inhibitor of Sirtuins and PARPs, it appears that reducing NADH plays a key role in the enhanced activity of NAD+-consuming enzymes. NAD+ levels can be boosted through food and commercially available supplements in addition to calorie restriction. NAD+ boosters such as NMN, NR, and niacin have been shown in small-scale human clinical research to increase NAD+ levels in volunteers and are relatively safe for human consumption.
2. NAD+ Levels and Exercise-
Because of the activation of skeletal muscle's NAMPT expression, which has been established in rodent and human research, aerobic exercise training or any type of exercise/sports activity increases the level of NAD+. Exercise training, in particular, reverses the age-dependent loss of NAD+ in human skeletal muscle by boosting the NAD+ salvage pathway, in which nicotinamide NAMPT is a rate-limiting enzyme. Exercise and aerobic sports activity boost NAD+ levels via inducing NAMPT expression in skeletal muscle, and stimulate the NAD+ salvage route via the 5 AMP-activated protein kinase (AMPK) pathways, reversing the age-dependent reduction of NAD+.
NAD+ plays a key function in the production of intracellular ATP, which is essential for exercise and sports. However, as previously stated, ATP synthesis in mitochondria is the primary source of free radical creation. The reduction state of complex I in mitochondria is greatly influenced by the amounts of NAD+ and NADH.
3. NAD+ Levels, Circadian Rhythms, and Sleeping Habits-
a consistent waking and sleeping cycle has been linked to improved health and longevity. Long-term disturbances of circadian rhythms have been linked to a variety of health problems. NAD+ levels and sirtuin activity work together to maintain a healthy circadian cycle of sleep and wakefulness; at the same time, the NAD+ level is regulated by the circadian clock. CLOCK : The BMAL1 heterodimer regulates NAD+ production by balancing the circadian expression of NAMPT. NAMPT activity decreases with age, and NAD+ bioavailability decreases as a result, causing the circadian rhythm to deteriorate (change in amplitude, period, and phase).
It's very important to keep a check on lifestyle related habits. All these habits play a vital role in ageing you right. Still confused? Learn the difference between chronological and biological age. This will help you know which part of your lifestyle you need to focus on, to remain young and healthy.